T
Tristan M. Nicholson
Researcher at University of Washington
Publications - 17
Citations - 664
Tristan M. Nicholson is an academic researcher from University of Washington. The author has contributed to research in topics: Lower urinary tract symptoms & Estrogen receptor. The author has an hindex of 10, co-authored 16 publications receiving 504 citations. Previous affiliations of Tristan M. Nicholson include University of Rochester & University of Wisconsin-Madison.
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Journal ArticleDOI
Androgens and estrogens in benign prostatic hyperplasia: past, present and future.
TL;DR: More work is needed to identify estrogens and associated signaling pathways in BPH in order to target BPH with dietary and therapeutic SERMs, and demonstrate that estrogen receptor signaling pathways may be important in the development and maintenance of BPH and LUTS.
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Testosterone and 17β-estradiol induce glandular prostatic growth, bladder outlet obstruction, and voiding dysfunction in male mice.
Tristan M. Nicholson,Emily A. Ricke,Paul C. Marker,Joseph M. Miano,Robert D. Mayer,Barry G. Timms,Frederick S. vom Saal,Ronald W. Wood,William A. Ricke +8 more
TL;DR: The constellation of lower urinary tract abnormalities, including BOO, enlarged prostates, and voiding dysfunction seen in male mice treated with T+E(2) is consistent with BPH in men, suitable for better understanding molecular mechanisms and for developing novel strategies to address BPH and BOO.
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Characterization of Fibrillar Collagens and Extracellular Matrix of Glandular Benign Prostatic Hyperplasia Nodules
Tyler M. Bauman,Tristan M. Nicholson,Lisa L. Abler,Kevin W. Eliceiri,Wei Huang,Chad M. Vezina,William A. Ricke +6 more
TL;DR: The proportion of larger bundles of collagen, but not total collagen, is increased in B PH nodules, suggesting that these large fibers may play a role in BPH/LUTS.
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Sex steroid receptor expression and localization in benign prostatic hyperplasia varies with tissue compartment
TL;DR: Tissue distribution and staining intensity of androgen receptor (AR) and estrogen receptor-alpha (ERα) and cells expressing both AR and ERα, in human BPH compared to normal prostate were quantitatively characterized and underscore the importance of tissue layer localization and expression of steroid hormone receptors in the prostate.
Journal ArticleDOI
Estrogen Receptor-α is a Key Mediator and Therapeutic Target for Bladder Complications of Benign Prostatic Hyperplasia
Tristan M. Nicholson,Tristan M. Nicholson,Michael A. Moses,Kristen S. Uchtmann,Kimberly P. Keil,Dale E. Bjorling,Chad M. Vezina,Ronald W. Wood,William A. Ricke +8 more
TL;DR: Estrogen receptor-α but not β is a key mediator of bladder complications of benign prostatic hyperplasia and a potential target for future therapies.