The synthesis of bacterial cellulose-chitosan zwitterionic hydrogels with pH responsiveness for drug release mechanism of the naproxen.

In this study, it was aimed to investigate the synthesis, characterization and drug release behaviors of organo-hydrogels containing pH-sensitive Agar (A), Glycerol (G), Sweet Almond oil (Wu et al. in J Mol Struct 882:107–115, 2008). Organo-hydrogels, which contained Agar, Glycerol and different amounts of Sweet Almond oil, were synthesized via the free-radical polymerization reaction with emulsion technique using glutaraldehyde or methylene bis acrylamide crosslinkers. Then, the degree of swelling, bond structures, blood compatibility and antioxidant properties of the synthesized organo-hydrogels were examined. In addition, Organo-hydrogels which loaded with Ceftriaxone and Oxaliplatin were synthesized with the same polymerization reaction and release kinetics were investigated. In vitro release studies were performed at media similar pH to gastric fluid (pH 2.0), skin surface (pH 5.5), blood fluid (pH 7.4) and intestinal fluid (pH 8.0), at 37 °C. The effects on release of crosslinker type and sweet almond oil amount were investigated. Kinetic parameters were determined using release results and these results were applied to zero and first-order equations and Korsmeyer-Peppas and Higuchi equations. Diffusion exponential was calculated for drug diffusion of organo-hydrogels and values consistent with release results were found.

/pdf/application-of-poly-agar-co-glycerol-co-sweet-almond-oil-1ywympiev9.pdf

Application of Poly (Agar-Co-Glycerol-Co-Sweet Almond Oil) Based Organo-Hydrogels as a Drug Delivery Material

Recent progress in the application of plant-based colloidal drug delivery systems in the pharmaceutical sciences.

Agar and Glycerol (AG) based Organo-hydrogels containing different cross-linkers and different amounts of Onion Oil were prepared in order to examine the in vitro release of the antibiotic drug Cef...

Development of onion oil-based organo-hydrogel for drug delivery material

A fabrication strategy for multifunctional organohydrogels is proposed, which combines phase-change microinclusions within a double-network (DN) hydrogel under the stabilization of Janus particles. Janus particles possess reactivity and colloidal stability for more robust organohydrogels, while the interstice among Janus particles enhances the mass transfer between the phase interfaces. Moreover, DN hydrogels are achieved through dynamic cross-linking networks, endowing organohydrogels with injectability and self-healing performance. Phase-change microinclusions are beneficial to the organohydrogels with temperature-responsive mechanical property and temperature-programed shape-memory performance. Organohydrogels can be employed for temperature therapy through the melting-crystallization process of phase-change microinclusions. Simultaneously, the payloads within microinclusions can be released for antibacteria upon melting the encapsulated wax. The organohydrogels can be served as an ideal dressing with temperature-responsive mechanical property, temperature therapy effectiveness, and temperature-triggered antibacterial ability.

Temperature-Sensitive Anti-Inflammatory Organohydrogels Containing Janus Particle Stabilized Phase-Change Microinclusions.

Developing poly(Agar-co-Glycerol-co-Thyme Oil) based Organo-hydrogels for the controlled drug release applications

In this study, six different organo-hydrogel containing Agar-Glycerol (AG) based Coconut Oil (CnO) were synthesized using different crosslinkers to ensure the controlled release of D3 Vitamine and 5-Fluorouracil (5-Flu). Synthesized organo-hydrogels were characterized by FT-IR, Afterwards, swelling behaviors were investigated in ethanol, acetone, ethanol/ID water (1:1), acetone /ID water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. The effects of the initial pH of the solution on the drug release process were investigated. It was observed that the most release occurred at pH 2 and glutaraldehyde crosslinker. Release kinetics models were applied to understand the mechanism of the release system of D3 Vitamine and 5-Flu (anti-cancer) with poly(Agar-co-Glycerol-co-Coconut Oil) (p(AG-co-CnO)) organo-hydrogel. The value of the correlation coefficient (R2) was used as the best model fit indicator of different models and it was determined that the balance data fit the Korsmeyer-Peppas with large R2s and the Higuchi kinetic model. The results showed that the p(AG-co-CnO) organo-hydrogel can be used as a suitable carrier for the controlled release of D3 Vitamin and 5-Flu.

Use of Coconut Oil-Based Organo-Hydrogels in Pharmaceutical Applications

In this study, six different organo-hydrogels containing agar-glycerol (AG)-based garlic oil (GO) were synthesized using two different crosslinkers (N,N, methylenebisacrylamide (MBA), glutaraldehyde (GA)) to ensure the controlled release of ceftriaxone (Ce) and carboplatin (Cp). Synthesized organo-hydrogels were characterized by FT-IR. Afterward, swelling behaviors were investigated in DI, tap water, ethanol, acetone, ethanol/DI water (1:1), acetone/DI water (1:1) and gasoline environments and different pH. As a result of hemolysis, blood clotting and antioxidant analysis, organo-hydrogels have been shown to have blood compatibility and antioxidant properties. Ce and Cp release properties of the prepared organo-hydrogels were also determined. The highest Ce release rate was obtained to be 37.8% for p (AG-g-GO)3 at pH 8.0 after 7 days. However, the highest Cp release rate was found to be 95.4% for p (AG-g-GO)3 at pH 7.4 after 1 day.

/pdf/a-garlic-oil-based-organo-hydrogel-for-use-in-ph-sensitive-1rpyh4f0bj.pdf

Tulü Olak

Papers

Developing poly(Agar-co-Glycerol-co-Thyme Oil) based Organo-hydrogels for the controlled drug release applications

Use of Coconut Oil-Based Organo-Hydrogels in Pharmaceutical Applications

A garlic oil-based organo-hydrogel for use in pH-sensitive drug release