Showing papers by "Tzi Bun Ng published in 1985"
TL;DR: This article reviews the recent progress in the identification of hypoglycemic and insulino-mimetic principles in ginseng and finds five glycans designated panaxans A to E, adenosine, a carboxylic acid, a peptide with a molecular weight of 1400 and lacking in basic amino acid residues, and a fraction designated DPG-3-2 prepared from the water extract of ginsENG.
Abstract: This article reviews the recent progress in the identification of hypoglycemic and insulino-mimetic principles in ginseng. Hitherto five types of substances have been discovered. They include five glycans designated panaxans A to E, adenosine, a carboxylic acid, a peptide with a molecular weight of 1400 and lacking in basic amino acid residues, and a fraction designated DPG-3-2 prepared from the water extract of ginseng. The structure of panaxan A has been partially elucidated and the glycans have been demonstrated to elicit hypoglycemia in both normal and diabetic mice. DPG-3-2 exerted its hypoglycemic action or provoked insulin secretion in diabetic and glucose-loaded normal mice while having no effect on normal mice. Adenosine, the carboxylic acid and the mol. wt 1400 peptide inhibited catecholamine-induced lipolysis in rat epididymal fat pads. EPG-3-2, a fraction related to DPG-3-2, also exhibited antilipolytic activity.
64 citations
TL;DR: The results indicated that M. charantia fruits and seeds contained components that resembled insulin in inhibiting hormone-induced lipolysis, and that compounds with antilipolytic activity were probably absent from T. kirilowii root tubers and C. maxima fruits and Seed.
24 citations
TL;DR: The lipogenic responses to EGF and NGF were additive with a submaximal response induced by insulin but not with that of a maximal response to insulin, indicating a similarity in the mechanisms of action of EGF, NGF and insulin.
Abstract: 1. 1. The effects of epidermal growth factor (EGF) and nerve growth factor (NGF) from mouse submaxillary glands on lipolysis and lipogenesis in isolated rat adipocytes were studied. 2. 2. EGF and NGF at nanomolar concentrations augmented basal lipogenesis. 3. 3. The lipogenic responses to EGF and NGF were additive with a submaximal response induced by insulin but not with that of a maximal response to insulin, indicating a similarity in the mechanisms of action of EGF, NGF and insulin. 4. 4. EGF and NGF also inhibited epinephrine-induced lipolysis. 5. 5. The antilipolytic and lipogenic activities of EGF and NGF were considerably less potent by concentration than those of insulin.
21 citations
8 citations
TL;DR: The galactose-binding lectin from the Chinese herb Trichosanthes kirilowii (Tianhuafen) stimulated the incorporation of D-[3-3H]glucose into lipids in isolated rat epididymal adipocytes, but did not inhibit lipolysis induced by either epinephrine or corticotropin in these adipocytes.
4 citations
TL;DR: The results suggest that the insulin receptor on rat adipocytes contains sialic acid in its carbohydrate moiety but does not possess non-reducing alpha-D-galactopyranosyl or 2-acetamido-2-deoxy-alpha-D
Abstract: 1. 1. Lectins from the horseshoe crab (Limulus polyphemus) and the garden snail (Helix pomatia) were tested for insulinomimetic activities in isolated rat epididymal adipocytes. 2. 2. The sialic acid binding horseshoe crab lectin suppressed epinephrine-induced lipolysis and augmented lipogenesis from d -[3-3H]-glucose while the N- acetylgalactosamine binding snail lectin was inactive. 3. 3. The results suggest that the insulin receptor on rat adipocytes contains sialic acid in its carbohydrate moiety but does not possess non-reducing α- d -galactopyranosyl or 2-acetamido-2-deoxy-α- d -galactopyranosyl end groups.
3 citations