U Y Khoo

TL;DR: In contrast with normal subjects where IgA is the main immunoglobulin in the intestine, patients with active inflammatory bowel disease (IBD) produce high concentrations of IgG from intestinal lymphocytes, but the antigens at which these antibodies are directed are unknown.

TL;DR: In this paper, T cells from the intestinal mucosal proliferate poorly in vitro, and the contribution of Ag-specific recognition to this hyporesponsiveness is unclear, since the Ag repertoire of intestinal T cells is unknown.

TL;DR: No specific binding to tropomyosin has been detected in serum samples or immunoglobulins isolated from mucosal washings of 20 ulcerative colitis patients by enzyme linked immunosorbent assay (ELISA) compared with 21 controls or 17 Crohn's disease patients.

TL;DR: The data suggest that mucosal T cell unresponsiveness to luminal Ags is mediated by production of inhibitory cytokines after specific Ag recognition by CD4+ T cells.

TL;DR: Work does not support the hypothesis thatautoimmune activity against theintestinal isoformor tropomyosin is important inthepathogenesis ofulcerative colitis, and the proteins inthe normal colonicbiopsyspecimens on westernblotst are bound by both serum samples and mucosalimmunoglobulin preparations.