U
Ulrich F. Schaefer
Researcher at Saarland University
Publications - 129
Citations - 8164
Ulrich F. Schaefer is an academic researcher from Saarland University. The author has contributed to research in topics: Human skin & Drug delivery. The author has an hindex of 50, co-authored 129 publications receiving 7358 citations. Previous affiliations of Ulrich F. Schaefer include University of Colorado Denver & Eastman Chemical Company.
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Journal ArticleDOI
Nanoparticles--an efficient carrier for drug delivery into the hair follicles.
Juergen Lademann,Heike Richter,A. Teichmann,Nina Otberg,Ulrike Blume-Peytavi,Javiana Luengo,Javiana Luengo,Barbara Weiss,Ulrich F. Schaefer,Claus-Michael Lehr,Roger Wepf,Wolfram Sterry +11 more
TL;DR: It was found that the nanoparticles penetrate much deeper into the hair follicles than the dye in the non-particle form, if a massage had been applied and without massage, similar results were obtained for both formulations.
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The human epidermis models EpiSkin, SkinEthic and EpiDerm: an evaluation of morphology and their suitability for testing phototoxicity, irritancy, corrosivity, and substance transport.
TL;DR: First results indicate their suitability for transport experiments of drugs and other xenobiotics across skin, but the barrier function of these reconstructed human epidermis models appears to be much less developed compared to native skin.
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Nanoparticles and their interactions with the dermal barrier
TL;DR: The interaction of nanoparticles with skin and especially skin models is an intriguing field, however, the data obtained do not show a clear image on the effect of nano-carriers and the penetration of such particles is an open and controversially discussed topic.
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Chitosan-coated PLGA nanoparticles for DNA/RNA delivery: effect of the formulation parameters on complexation and transfection of antisense oligonucleotides
TL;DR: The study proved the efficacy of chitosan-coated PLGA nanoparticles as a flexible and efficient delivery system for antisense oligonucleotides to lung cancer cells.
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Nanoparticles made from novel starch derivatives for transdermal drug delivery
Manuel J. Santander-Ortega,Manuel J. Santander-Ortega,Thomas Stauner,Brigitta Loretz,Juan Luis Ortega-Vinuesa,Delfi Bastos-González,Gerhard Wenz,Ulrich F. Schaefer,Claus-Michael Lehr +8 more
TL;DR: Encapsulation and release properties of these nanoparticles were studied, showing high encapsulation efficiency for three tested drugs and a close to linear release profile was observed for hydrophobic drugs with a null initial burst effect.