Wolfram Sterry

TL;DR: It is demonstrated that IL‐22, in contrast to its relative IFN‐γ, regulates the expression of only a few genes in keratinocytes, which may be important in the innate immunity and reorganization of epithelia.

TL;DR: It was found that the nanoparticles penetrate much deeper into the hair follicles than the dye in the non-particle form, if a massage had been applied and without massage, similar results were obtained for both formulations.

TL;DR: It is postulated that the pathogenesis of psoriasis consists of distinct subsequent stages, in each of them different cell types playing a dominant role, which helps to explain the varied effectiveness of the currently tested immune modulating therapies and may enable the prediction of the success of future therapies.

TL;DR: The structure of porcine ear skin, including hair follicles, was studied qualitatively and quantitatively in comparison with human skin in studies of percutaneous penetration.

TL;DR: It is suggested that different cytokines are players in the psoriasis pathogenesis although only the IL-10 family members IL-22 and IL-20 directly cause the characteristic epidermal alterations.