Ulrich Klar

TL;DR: A new class of borneol esters that might be considered as biological analogs of paclitaxel regarding their action on microtubules has been found by structure-activity optimizations, and will open completely new therapeutic areas.

TL;DR: In this article, the Epothilone derivatives of formula (I) are new and are prepared from a number of new and known starting compounds, and they have the same meanings as R a, R b and R b, provided that when D-E is CH2-CH2 or Y is O, then R a and Rb are not H or CH3; R, R = H, 1-10C alkyl, aryl or 7-20C aralkyl, which are all optionally substituted.

TL;DR: The conformation of 11β-arylandrostenes is discussed in comparison with known antiprogestational steroids and conformational changes of the steroid ring system that result in reduced affinity for the progesterone receptor are discussed.

TL;DR: A novel, highly potent progesterone receptor antagonist, ZK 230211, has been identified after introduction of a 17α-pentafluoroethyl side chain into the D-ring of the steroidal skeleton resulted in a compound that combines a pure anti-progestagenic endocrinological profile with high potency.