Journal ArticleDOI
Total Synthesis and Antitumor Activity of ZK‐EPO: The First Fully Synthetic Epothilone in Clinical Development
Ulrich Klar,Bernd Buchmann,Wolfgang Schwede,Werner Skuballa,Jens Hoffmann,Rosemarie Lichtner +5 more
About:
This article is published in Angewandte Chemie.The article was published on 2006-12-04. It has received 127 citations till now. The article focuses on the topics: Epothilone.read more
Citations
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Natural products: a continuing source of novel drug leads.
Gordon M. Cragg,David J. Newman +1 more
TL;DR: This review traces natural products drug discovery, outlining important drugs from natural sources that revolutionized treatment of serious diseases and effective drug development depends on multidisciplinary collaborations.
Journal ArticleDOI
Natural products to drugs: natural product derived compounds in clinical trials
Mark S. Butler,Mark S. Butler +1 more
TL;DR: Natural product and natural product-derived compounds that are being evaluated in clinical trials or are in registration (as at 31st December 2007) have been reviewed, as well as natural products for which clinical trials have been halted or discontinued since 2005.
Journal ArticleDOI
Natural products: an evolving role in future drug discovery.
Bhuwan B. Mishra,Vinod K. Tiwari +1 more
TL;DR: The present review describes natural products, semi-synthetic NPs and NP-derived compounds that have undergone clinical evaluation or registration from 2005 to 2010 by disease area i.e. infectious, immunological, cardiovascular, neurological, inflammatory and related diseases and oncology.
Journal ArticleDOI
Tubulin-interactive natural products as anticancer agents.
TL;DR: The vinca alkaloids, the combretastatins, NPI-2358, the halichondrin B analogue eribulin, dolastatin 10, noscapine, hemiasterlin, and rhizoxin are discussed as tubulin polymerization inhibitors, while the taxanes and the epothilones are the major classes of tubulin polymers presented.
Patent
Cyclodextrin-based polymers for therapeutics delivery
TL;DR: In this paper, the authors present novel compositions of therapeutic cyclodextrin containing polymeric compounds designed as a carrier for small molecule therapeutics delivery and pharmaceutical compositions thereof, which improve drug stability and solubility, and reduce toxicity of the small molecule therapeutic when used in vivo.
References
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Journal Article
Epothilones, a New Class of Microtubule-stabilizing Agents with a Taxol-like Mechanism of Action
Daniel M. Bollag,Patricia A. McQueney,Jian Zhu,Otto D. Hensens,Lawrence R. Koupal,Jerrold M. Liesch,Michael A. Goetz,Elias Lazarides,Catherine M. Woods +8 more
TL;DR: Epothilones represent a novel structural class of compounds, the first to be described since the original discovery ofTaxol, which not only mimic the biological effects of taxol but also appear to bind to the same microtubule-binding site as taxol.
Journal ArticleDOI
Epothilons A and B: antifungal and cytotoxic compounds from Sorangium cellulosum (Myxobacteria). Production, physico-chemical and biological properties.
TL;DR: An antifungal activity against Mucor hiemalis was detected in the culture broth of Sorangium cellulosum strain So ce90 and the epothilons showed a high cytotoxicity for animal cells and mimic the biological effects of taxol.
Journal ArticleDOI
Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution†
Gerhard Höfle,Norbert Bedorf,Heinrich Steinmetz,Dietmar Schomburg,Klaus Gerth,Hans Reichenbach +5 more
Journal Article
BMS-247550: a novel epothilone analog with a mode of action similar to paclitaxel but possessing superior antitumor efficacy.
Francis Y. Lee,Robert M. Borzilleri,Craig R. Fairchild,Soong-Hoon Kim,Byron H. Long,Carmen Reventos-Suarez,Gregory D. Vite,William C. Rose,Robert A. Kramer +8 more
TL;DR: Efficacy data demonstrate that BMS-247550 has the potential to surpass Taxol in both clinical efficacy and ease of use (i.e., less frequent treatment schedule and/or oral administration).