Showing papers by "Ulrich Speck published in 2012"
TL;DR: Treatment of coronary ISR with paclitaxel-coated balloon catheters is safe and persistently reduces repeat revascularization during long-term follow-up.
Abstract: Objectives: This study presents long-term clinical follow-up, including binary restenosis rate and major adverse cardiovascular events, of the PACCOCATH-ISR (Treatment of In-Stent Restenosis by Pac...
199 citations
TL;DR: The impact of different kinds of balloons, drugs, additives, and coating methods has been investigated, and the results of representative examples including clinically tested products are presented and discussed.
Abstract: Flow-limiting stenosis or total occlusion of coronary, cerebral, or peripheral arteries is very common. Minimally invasive treatment with balloon catheters optionally combined with stent implantation immediately relieves symptoms. However, renarrowing of dilated vessel segments due to excessive scar formation frequently reverses the initial success observed soon after treatment. Coating of balloons with antiproliferative drugs is a promising approach to overcome this problem. The coating of angioplasty balloon membranes is a challenging task. It must ensure homogeneous distribution of the antiproliferative agent and adherence to the balloon membrane during handling and on the way to the treatment site in a distant artery, where the agent should be immediately released and transferred to the vessel wall when the balloon is inflated. In vitro and in vivo testing methods are described. The impact of different kinds of balloons, drugs, additives, and coating methods has been investigated, and the results of representative examples including clinically tested products are presented and discussed.
14 citations
Patent•
23 Feb 2012
TL;DR: In this paper, a solid X-ray contrast medium comprising microspheres for depicting the gastrointestinal tract, with a cavity volume of at least 25% of the total volume, the cavity containing at least one gas, was described.
Abstract: The invention relates to a solid X-ray contrast medium comprising microspheres for depicting the gastrointestinal tract, with a cavity volume of at least 25% of the total volume, the cavity containing at least one gas, and the medium being characterized in that the microspheres are embedded in a dry binder. The invention further relates to the production of this X-ray contrast medium and also to its use.
Patent•
23 Feb 2012
TL;DR: In this article, the authors find ein festes Rontgenkontrastmittel umfassend Microspharen fur die Darstellung des Gastrointestinaltraktes with einem Hohlraumvolumen von mindestens 25% des Gesamtvolumens.
Abstract: Die Erfindung betrifft ein festes Rontgenkontrastmittel umfassend Microspharen fur die Darstellung des Gastrointestinaltraktes mit einem Hohlraumvolumen von mindestens 25% des Gesamtvolumens, wobei im Hohlraum mindestens ein Gas enthalten ist, und welches dadurch gekennzeichnet ist, dass die Microspharen in ein trockenes Bindemittel, eingebettet sind. Weiterhin betrifft die Erfindung die Herstellung dieses Rontgenkontrastmittels sowie dessen Verwendung.