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Ulrika S. H. Simonsson
Researcher at Uppsala University
Publications - 107
Citations - 2734
Ulrika S. H. Simonsson is an academic researcher from Uppsala University. The author has contributed to research in topics: Population & Medicine. The author has an hindex of 27, co-authored 87 publications receiving 2240 citations. Previous affiliations of Ulrika S. H. Simonsson include Karolinska Institutet & AstraZeneca.
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Journal ArticleDOI
In vivo blood-brain barrier transport of oxycodone in the rat: indications for active influx and implications for pharmacokinetics/pharmacodynamics.
TL;DR: This is the first evidence of an opioid having an unbound steady-state concentration in brain that is higher than unity, which can explain potency discrepancies between oxycodone and other opioids.
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Population Pharmacokinetics of Rifampin in Pulmonary Tuberculosis Patients, Including a Semimechanistic Model To Describe Variable Absorption
Justin J. Wilkins,Radojka M. Savic,Mats O. Karlsson,Grant Langdon,Grant Langdon,Helen McIlleron,Goonaseelan Pillai,Pete Smith,Ulrika S. H. Simonsson +8 more
TL;DR: A strong correlation between clearance and volume of distribution suggested substantial variability in bioavailability, which could have clinical implications, given the dependence of treatment effectiveness on exposure.
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Blood–Brain Barrier Transport Helps to Explain Discrepancies in In Vivo Potency between Oxycodone and Morphine
TL;DR: For centrally acting drugs such as opioids, pharmacokinetic–pharmacodynamic relations describing the interaction with the receptor are better obtained by correlating the effects to concentrations of unbound drug in the tissue of interest rather than to blood concentrations.
Journal ArticleDOI
Variability in the population pharmacokinetics of isoniazid in South African tuberculosis patients.
Justin J. Wilkins,Grant Langdon,Grant Langdon,Helen McIlleron,Goonaseelan Pillai,Pete Smith,Ulrika S. H. Simonsson +6 more
TL;DR: Simulations suggested that current treatment guidelines may be suboptimal in fast eliminators with low body weight, which may lead to underexposure in rapid isoniazid eliminators.
Journal ArticleDOI
Artemisinin autoinduction is caused by involvement of cytochrome P450 2B6 but not 2C9.
Ulrika S. H. Simonsson,Ulrika S. H. Simonsson,Britt Jansson,Britt Jansson,Trinh Ngoc Hai,Trinh Ngoc Hai,Dinh Xuan Huong,Dinh Xuan Huong,Gunnel Tybring,Gunnel Tybring,Michael Ashton,Michael Ashton +11 more
TL;DR: The effects of multiple‐dose artemisinin administration on S‐mephenytoin N‐demethylation in healthy subjects is evaluated.