H
Helen McIlleron
Researcher at University of Cape Town
Publications - 188
Citations - 7668
Helen McIlleron is an academic researcher from University of Cape Town. The author has contributed to research in topics: Population & Pyrazinamide. The author has an hindex of 43, co-authored 167 publications receiving 6462 citations. Previous affiliations of Helen McIlleron include Groote Schuur Hospital.
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Journal ArticleDOI
The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis
Keertan Dheda,Tawanda Gumbo,Gary Maartens,Kelly E. Dooley,Ruth McNerney,Megan Murray,Jennifer Furin,Edward A. Nardell,Leslie London,Erica Lessem,Grant Theron,Paul D. van Helden,Stefan Niemann,Matthias Merker,David W. Dowdy,Annelies Van Rie,Annelies Van Rie,Gilman Kit Hang Siu,Jotam G. Pasipanodya,Camilla Rodrigues,Taane G. Clark,F. A. Sirgel,Aliasgar Esmail,Hsien-Ho Lin,Sachin R Atre,H. Simon Schaaf,Kwok Chiu Chang,Christoph Lange,Payam Nahid,Zarir F Udwadia,C. Robert Horsburgh,Gavin J. Churchyard,Gavin J. Churchyard,Dick Menzies,Anneke C. Hesseling,Eric L. Nuermberger,Helen McIlleron,Kevin P. Fennelly,Eric Goemaere,Ernesto Jaramillo,Marcus Low,Carolina Morán Jara,Nesri Padayatchi,Robin M. Warren +43 more
TL;DR: Several lines of evidence suggest that alternative mechanisms-including pharmacokinetic variability, induction of efflux pumps that transport the drug out of cells, and suboptimal drug penetration into tuberculosis lesions-are likely crucial to the pathogenesis of drug-resistant tuberculosis.
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Serum Drug Concentrations Predictive of Pulmonary Tuberculosis Outcomes
TL;DR: Low drug AUCs are predictive of clinical outcomes in tuberculosis patients, and low rifampin and isoniazid peak and AUC concentrations preceded all cases of acquired drug resistance.
Journal ArticleDOI
Global tuberculosis drug development pipeline: the need and the reality
TL;DR: To eliminate tuberculosis as a public health concern by 2050, all responsible parties need to work together to strengthen the global antituberculosis drug pipeline and support the development of new antituber tuberculosis drug regimens.
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High-Dose Rifapentine with Moxifloxacin for Pulmonary Tuberculosis
Amina Jindani,Thomas S. Harrison,Andrew J. Nunn,Patrick P. J. Phillips,Gavin J. Churchyard,Salome Charalambous,Mark Hatherill,Hennie Geldenhuys,Helen McIlleron,Simbarashe P. Zvada,Stanley Mungofa,Nasir A. Shah,Simukai Zizhou,Lloyd Magweta,James Shepherd,Sambayawo Nyirenda,Janneke H. van Dijk,Heather Clouting,David Coleman,Anna L.E. Bateson,Timothy D. McHugh,Philip D. Butcher,Denny A. Mitchison +22 more
TL;DR: The 6-month regimen that included weekly administration of high-dose rifapentine and moxifloxacin was as effective as the control regimen and the 4- month regimen was not noninferior to thecontrol regimen.
Journal ArticleDOI
Research capacity. Enabling the genomic revolution in Africa
Charles N. Rotimi,Akin Abayomi,Alash'le Abimiku,Victoria Adabayeri,Clement Adebamowo,Ezekiel Adebiyi,Adebowale D. Ademola,Adebowale Adeyemo,Dwomoa Adu,Dissou Affolabi,Godfred Agongo,Samuel Ajayi,Sally N Akarolo-Anthony,Rufus Akinyemi,Albert Akpalu,Marianne Alberts,Orlando Alonso Betancourt,Ahmed M. Alzohairy,Gobena Ameni,Olukemi K. Amodu,Gabriel Anabwani,Kristian G. Andersen,Fatiu A Arogundade,Oyedunni Arulogun,Danny Asogun,Rasheed Bakare,Naby Balde,Mary Lynn Baniecki,Christine Beiswanger,Alia Benkahla,Lara Bethke,M Boehnke,Vincent Boima,James Brandful,Andrew Brooks,Frank C. Brosius,Chester W. Brown,Bruno Bucheton,David T. Burke,Barrington G. Burnett,Stacy Carrington-Lawrence,Nadia Carstens,John Chisi,Alan Christoffels,Richard S. Cooper,Heather J. Cordell,Nigel J. Crowther,Talishiea Croxton,Jantina de Vries,Leslie Derr,Peter Donkor,Seydou Doumbia,Audrey Duncanson,Ivy Ekem,Ahmed El Sayed,Mark E Engel,John Enyaru,Dean Everett,Faisal M. Fadlelmola,Eyitayo Fakunle,Kenneth H. Fischbeck,Anne Fischer,Onikepe A. Folarin,Junaid Gamieldien,Robert F. Garry,Simani Gaseitsiwe,Rasheed Gbadegesin,Anita Ghansah,Maria Y. Giovanni,Parham Goesbeck,F. Xavier Gómez-Olivé,Donald S. Grant,Ravnit Grewal,Mark S. Guyer,Neil A. Hanchard,Christian T. Happi,Scott Hazelhurst,Branwen J. Hennig,Christiane Hertz-Fowler,Winston Hide,Friedhelm Hilderbrandt,Christopher Hugo-Hamman,Muntaser E. Ibrahim,Regina James,Yasmina Jaufeerally-Fakim,Carolyn Jenkins,Ute Jentsch,Pan Pan Jiang,Moses Joloba,Victor Jongeneel,Fourie Joubert,Mukthar Kader,Kathleen Kahn,Pontiano Kaleebu,Saidi Kapiga,Samar K. Kassim,Ishmael Kasvosve,Jonathan K. Kayondo,Bernard Keavney,Adeodata Kekitiinwa,Sheik Humarr Khan,Paul L. Kimmel,Mary Claire King,Robert Kleta,Mathurin Koffi,Jeffrey B. Kopp,Matthias Kretzler,Judit Kumuthini,Samuel Kyobe,Catherine Kyobutungi,Daniel T. Lackland,Karen A. Lacourciere,Guida Landouré,Rita T. Lawlor,Thomas Lehner,Maia Lesosky,Naomi S. Levitt,Katherine Littler,Zané Lombard,Jeanne F. Loring,Sylvester Leonard Lyantagaye,Annette MacLeod,Ebony B. Madden,Chengetai R. Mahomva.,Julie Makani,Manmak Mamven,Marape Marape,Graeme Mardon,Patricia A. Marshall,Darren P. Martin,Daniel K. Masiga,Robin Mason,Michael Mate-Kole,Enock Matovu,Mary T Mayige,Mary T Mayige,Bongani M. Mayosi,Jean Claude Mbanya,Sheryl A. McCurdy,Mark I. McCarthy,Helen McIlleron,Seth O. McLigeyo,Corrine Merle,Ana Olga Mocumbi,Charles Mondo,John V. Moran,Ayesha A. Motala,Marva Moxey-Mims,Sununguko Wata Mpoloka,Chisomo L. Msefula,Thuli Mthiyane,Nicola Mulder,Gebregziabher Mulugeta,Dieuodonne Mumba,John Musuku,Mo Nagdee,Oyekanmi Nash,Daouda Ndiaye,Anh Quynh Nguyen,Mark P. Nicol,Oathokwa Nkomazana,Shane A. Norris,Betty Nsangi,Alexander K. Nyarko,Moffat Nyirenda,Eileen Obe,Reginald Obiakor,Abraham Oduro,Solomon F. Ofori-Acquah,Okechukwu S Ogah,S.W.O. Ogendo,Kwaku Ohene-Frempong,Akinlolu O. Ojo,T O Olanrewaju,John Oli,Charlotte Osafo,Odile Ouwe Missi Oukem-Boyer,Bruce Ovbiagele,Andrew Owen,Mayowa O. Owolabi,Lukman Owolabi,Ellis Owusu-Dabo,Guillaume Paré,Rulan S. Parekh,Hugh-G. Patterton,Margaret B. Penno.,Jane Peterson,Rembert Pieper,Jacob Plange-Rhule,Martin R. Pollak,Julia Puzak,Rajkumar Ramesar,Michèle Ramsay,Rebekah S. Rasooly,Shiksha Reddy,Pardis C. Sabeti,Kwamena W. Sagoe,Tunde Salako,Oumar Samassekou,Manjinder S. Sandhu,Manjinder S. Sandhu,Manjinder S. Sandhu,Osman Sankoh,Fred Stephen Sarfo,Marie Sarr,Gasnat Shaboodien,Issa Sidibe,Gustave Simo,Martin Simuunza,Liam Smeeth,Eugene Sobngwi,Himla Soodyall,Hermann Sorgho,Oumou Sow Bah,Sudha Srinivasan,Dan J. Stein,Ezra Susser,Carmen Swanepoel,Godfred Tangwa,Andrew Tareila,Özlem Tastan Bishop,Bamidele O. Tayo,Nicki Tiffin,Halidou Tinto,Ekaete Tobin,Stephen Tollman,Mahamadou Traoré,Marsha Treadwell,Jennifer L. Troyer,Masego Tsimako-Johnstone,Vincent Tukei,Ifeoma Ulasi,Nzovu Ulenga,Beverley van Rooyen,Ablo Prudence Wachinou,Salina P. Waddy,Alisha N. Wade,Misaki Wayengera,James A. G. Whitworth,Louise Wideroff,Cheryl A. Winkler,Sarah Winnicki,Ambroise Wonkam,Mengistu Tadase Yewondwossen,Nathan L. Yozwiak,Heather J. Zar +245 more
TL;DR: If the dearth of genomics research involving Africans persists, the potential health and economic benefits emanating from genomic science may elude an entire continent.