U
Umesh Chandra Halder
Researcher at Indian Council of Medical Research
Publications - 8
Citations - 292
Umesh Chandra Halder is an academic researcher from Indian Council of Medical Research. The author has contributed to research in topics: NSP1 & Viral protein. The author has an hindex of 7, co-authored 8 publications receiving 260 citations.
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Journal ArticleDOI
Rotavirus Nonstructural Protein 1 Suppresses Virus-Induced Cellular Apoptosis To Facilitate Viral Growth by Activating the Cell Survival Pathways during Early Stages of Infection
Parikshit Bagchi,Dipanjan Dutta,Shiladitya Chattopadhyay,Anupam Mukherjee,Umesh Chandra Halder,Sagartirtha Sarkar,Nobumichi Kobayashi,Satoshi Komoto,Koki Taniguchi,Mamta Chawla-Sarkar +9 more
TL;DR: The data suggest that NSP1 positively supports rotavirus growth by suppression of premature apoptosis for improved virus growth after infection.
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Rotaviral Enterotoxin Nonstructural Protein 4 Targets Mitochondria for Activation of Apoptosis during Infection
Rahul Bhowmick,Umesh Chandra Halder,Shiladitya Chattopadhyay,Shampa Chanda,Satabdi Nandi,Parikshit Bagchi,Mukti Kant Nayak,Oishee Chakrabarti,Nobumichi Kobayashi,Mamta Chawla-Sarkar +9 more
TL;DR: This study shows translocation of NSP4 to mitochondria, dissipation of mitochondrial potential, and initiation of apoptosis, which NSP1 counteracts during early infection, indicating modulation of cellular survival and apoptotic machinery by rotavirus for their own benefit.
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Cell death regulation during influenza A virus infection by matrix (M1) protein: a model of viral control over the cellular survival pathway
Umesh Chandra Halder,Parikshit Bagchi,Shiladitya Chattopadhyay,Dipanjan Dutta,Mamta Chawla-Sarkar +4 more
TL;DR: It is shown that influenza A virus can regulate the anti-apoptotic function of Hsp70 through viral protein M1 (matrix 1).
Journal ArticleDOI
Rotavirus-Encoded Nonstructural Protein 1 Modulates Cellular Apoptotic Machinery by Targeting Tumor Suppressor Protein p53
Rahul Bhowmick,Umesh Chandra Halder,Shiladitya Chattopadhyay,Mukti Kant Nayak,Mamta Chawla-Sarkar +4 more
TL;DR: During late viral infection, when progeny dissemination is the main objective, the NSP1-p53 interaction was diminished, resulting in restoration of the p53 level, with initiation of proapoptotic signaling ensuing, highlighting the multiple strategies evolved by NSP 1 to combat the host immune response.
Journal ArticleDOI
Active Participation of Cellular Chaperone Hsp90 in Regulating the Function of Rotavirus Nonstructural Protein 3 (NSP3)
Dipanjan Dutta,Shiladitya Chattopadhyay,Parikshit Bagchi,Umesh Chandra Halder,Satabdi Nandi,Anupam Mukherjee,Nobumichi Kobayashi,Koki Taniguchi,Mamta Chawla-Sarkar +8 more
TL;DR: The active association of Hsp90 in the folding and stabilization of rotavirus nonstructural protein 3 (NSP3) is reported and the crucial role of HSp90 chaperone in the regulation of assembly and functionality of a viral protein during the virus replication and propagation in host cells is highlighted.