R
Rahul Bhowmick
Researcher at University of Copenhagen
Publications - 32
Citations - 1148
Rahul Bhowmick is an academic researcher from University of Copenhagen. The author has contributed to research in topics: DNA replication & Genome instability. The author has an hindex of 17, co-authored 25 publications receiving 850 citations.
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Journal ArticleDOI
RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress
TL;DR: It is reported that RAD51 and BRCA2 are dispensable for MiDAS but are required to counteract replication stress at CFS loci during S-phase, andMiDAS is RAD52 dependent, and RAD52 is required for the timely recruitment of MUS81 and POLD3 to CFSs in early mitosis.
Journal ArticleDOI
Antiviral activity of baicalin against influenza virus H1N1-pdm09 is due to modulation of NS1-mediated cellular innate immune responses
Mukti Kant Nayak,Anurodh S. Agrawal,Sudeshna Bose,Shaon Naskar,Rahul Bhowmick,Saikat Chakrabarti,Sagartirtha Sarkar,Mamta Chawla-Sarkar +7 more
TL;DR: This study highlights that baicalin exerts its anti-influenza virus activity by modulating viral protein NS1, resulting in up-regulation of IFN-induced antiviral signalling and a decrease in PI3K/Akt signalling in cells.
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RECQ5 Helicase Cooperates with MUS81 Endonuclease in Processing Stalled Replication Forks at Common Fragile Sites during Mitosis.
Stefano Di Marco,Zdenka Hasanova,Radhakrishnan Kanagaraj,Nagaraja Chappidi,Veronika Altmannova,Shruti Menon,Hana Sedlackova,Jana Langhoff,Kalpana Surendranath,Daniela Hühn,Rahul Bhowmick,Victoria Marini,Stefano Ferrari,Ian D. Hickson,Lumir Krejci,Pavel Janscak +15 more
TL;DR: Biochemically, RECQ5 removes RAD51 filaments stabilizing stalled replication forks at CFSs and hence facilitates CFS cleavage by MUS81-EME1 through its RAD51 filament disruption activity.
Journal ArticleDOI
High-resolution mapping of mitotic DNA synthesis regions and common fragile sites in the human genome through direct sequencing.
Morgane Macheret,Rahul Bhowmick,Katarzyna Sobkowiak,Laura Padayachy,Jonathan Mailler,Ian D. Hickson,Thanos D. Halazonetis +6 more
TL;DR: This work mapped, at high resolution, the genomic sites of MiDAS in cells treated with the DNA polymerase inhibitor aphidicolin, and found leading and lagging strand synthesis were uncoupled inMiDAS, consistent with MiDas being a form of break-induced replication, a repair mechanism for collapsed DNA replication forks.
Journal ArticleDOI
Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism.
TL;DR: A model whereby replication stress initiates a RAD52-dependent form of break-induced replication that bypasses a requirement for MUS81-EME1 to complete DNA synthesis in mitosis is proposed.