The Dopamine Hypothesis of Schizophrenia: A Review*

Novel compounds, their salts and compositions related thereto having activity against mammalian factor Xa are disclosed. The compounds are useful in vitro or in vivo for preventing or treating coagulation disorders.

Inhibitors of factor xa

Biochemical, structural, genetic, physiological, and pathophysiological features of lipocalin-type prostaglandin D synthase.

Prostaglandin (PG) D synthase catalyzes the isomerization of PGH2, a common precursor of various prostanoids, to produce PGD2 in the presence of sulfhydryl compounds PGD2 induces sleep, regulates nociception, inhibits platelet aggregation, acts as an allergic mediator, and is further converted to 9 alpha, 11 beta-PGF2 or the J series of prostanoids, such as PGJ2, delta 12-PGJ2, and 15-deoxy-delta 12,14-PGJ2 We have purified two distinct types of PGD synthase; one is the lipocalin-type enzyme and the other is the hematopoietic enzyme We isolated the cDNA and the gene for each enzyme and determined the tissue distribution profile and the cellular localization in several animal species Lipocalin-type PGD synthase is localized in the central nervous system and male genital organs of various mammals and the human heart and is secreted into cerebrospinal fluid, seminal plasma, and plasma, respectively The human enzyme was identified as beta-trace, which is a major protein in human cerebrospinal fluid This enzyme is considered to be a dual-function protein; it acts as a PGD2-producing enzyme and also as a lipophilic ligand-binding protein, because the enzyme binds retinoids, thyroids, and bile pigments, with high affinities Hematopoietic PGD synthase is widely distributed in the peripheral tissues and localized in the antigen-presenting cells, mast cells, and megakaryocytes The hematopoietic enzyme is the first recognized vertebrate homolog of the sigma class of glutathione S-transferase X-ray crystallographic analyses and generation of gene-knockout and transgenic mice for each enzyme have been performed

Prostaglandin D synthase: structure and function.

✓ In this review of spinal cord injury research, the author has selected contributions which in his opinion best represent modern experimental concepts regarding the mechanism and management of spinal cord injuries. He has placed special emphasis on the controversial issues appropriate to a new, stimulating, and competitive area of research.

The pathophysiological response to spinal cord injury. The current status of related research.

Inhibition of dopamine β-hydroxylase by fusaric acid (5-butylpicolinic acid) in vitro and in vivo

Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids.

Effect of oudenone on adrenal tyrosine hydroxylase activity in vivo and on tissue catecholamine concentrations.

WHEREIN N, R1, R2, R3 are the same as described above. WHEREIN N, R1, R2, R3 are the same as described above, or the compound represented by the general formula: WHICH COMPRISES CHEMICALLY TREATING THE COMPOUND REPRESENTED BY THE GENERAL FORMULA: WHEREIN N 1 OR 0 R3 alkyl radical Synthesis of leupeptins and their analogues represented by the general formula:

Process for the synthesis of leupeptins and their analogues

PURPOSE:To provide an antiallergic agent and bronchodilator containing a novel physiologically active substance plipastatin or its salt as an active component CONSTITUTION:The objective antiallergic agent or bronchodilator contains, as an active component, the compound of formula (R1 is C13H27 or C14H29; R2 is Ala or Val; Glu, Orn Tyr, Thr, Pro, Gln, Ile, Ala and Val represent glutamic acid, ornithine, tyrosine, threonine, proline, glutamine, isoleucine, alanine and valine, respectively) or its salt which is a physiologically active substance produced eg by Bacillus sereus BMG302-fF67 (FERM P-7843) The compound suppresses the I-type allergy such as asthma, pollinosis and atopic dermatitis, etc, and has string action to relax the smooth muscule of trachea Accordingly, it is useful for the remedy of closed pulmonary disease, and also has relatively low toxicity

Umezawa Hamao

Papers

Inhibition of dopamine β-hydroxylase by fusaric acid (5-butylpicolinic acid) in vitro and in vivo

Inhibition of brain prostaglandin D synthetase and prostaglandin D2 dehydrogenase by some saturated and unsaturated fatty acids.

Effect of oudenone on adrenal tyrosine hydroxylase activity in vivo and on tissue catecholamine concentrations.

Process for the synthesis of leupeptins and their analogues

Antiallergic agent and bronchodilator