Showing papers in "Biochemical Pharmacology in 1971"

TL;DR: A sensitive, fixed-time, spectrophotometric assay for angiotensin-converting enzyme measures the rate of production of hippuric acid from hippuryl-L -histidyl- L -leucine (HHL).

TL;DR: Oral administration of (+)-catechin to man results in absorption, rapid metabolism and excretion of the compound largely within 24 hr, and several unidentified metabolites are detected in the urine together with several unidentified metabolite both in the free and conjugated forms.

TL;DR: It was apparent that the ionic strength of the preparative medium is more important than either molarity or pH for obtaining microsomes of maximum N- and O-demethylating activity.

TL;DR: Sodium fluoride-induced adenyl cyclase activity of rat and rabbit cerebral cortex homogenates is inhibited by a wide range of concentrations of lithium, suggesting that the psychosedative effects of lithium may be related to the inhibition of brain adenYL cyclase.

TL;DR: The results of these studies indicate that considerable caution must be exercised in the preparation, handling and incubation of lysosomes in order to reveal the stabilizing capacity in vitro of anti-inflammatory drugs.

TL;DR: The lag phase of about 4 hr before accumulation of the acids in lumbar CSF occurs, might reflect on the transport time along the spinal cord of the acid from the cisteraal- to the lumbAR region.

TL;DR: The differences between the physicochemical properties of platelet MAO and isoenzymes from other anatomical sites suggests that the platelet enzyme is unlikely to provide a satisfactory index of in vivo activity in the whole organism.

TL;DR: Four substrates (hexobarbital, imipramine, p -nitroanisol and aminopyrine) are metabolized by rat liver with a rhythm showing a minimum or a maximum with a change in drug metabolism, and the possibility that neuroendocrine factors may be responsible for the daily rhythm of drug metabolism is discussed.

TL;DR: Evidence suggests that the conversion of NDZ to hydroxyaminothiamidazol by liver microsomes is mediated by NADPH-cytochrome c reductase.

TL;DR: Ferreira et al. as discussed by the authors synthesized a bradykinin potentiating peptide from Bothrops jararaca venom, which had the same spectrum of pharmacological properties as previously reported for Bradykinin Potentiating Factor.

TL;DR: Liver blood flow increased by 33–175 per cent above control values in rats treated with phenobarbitone and antipyrine but not in those given benzpyrene, suggesting that the increase in liver blood flow may be due to increases in liver weight and enzyme activity.

TL;DR: Structural-activity relationships suggested that position six of 2-formylpyridine thiosemicarbazone and position three of 1- formylisoquinoline thiosine are comparable with respect to orientation at the inhibitor binding site and that the enzyme has little bulk tolerance at this locus.

TL;DR: Data obtained for DB-c-AMP, phosphodiesterase inhibitors and PGE1 can be viewed as circumstantial evidence in support of a role for c-AMP in the histamine release process of the mast cell.

TL;DR: Methods have been devised for the preparation and characterization of the potassium salts of 2-deoxy-2-[35S] sulphoamino- d -glucose, [35S]:serine, Heparin and Chitosan for use in studies on mammalian enzymes involved in the degradation of sulphamate groupings in heparin.

TL;DR: Differences in distribution between various mercury compounds seem to be related to the stability of the carbon-mercury bond, lysosomes accumulating inorganic mercury by preference either injected as such, or released in vivo from the intact organomercurial.

TL;DR: A correlation was found between the degree ofDDT inhibition of ATPases and the electrophysiological symptoms of DDT poisoning and a variety of neuroactive agents which are known to induce the nerve conductance changes were examined for their actions on the ATPase preparations.

TL;DR: The soluble fraction of liver contains an enzyme that catalyzes the reduction of niridazole by either NADH or hypoxanthine, and, on purification of the enzyme, xanthine oxidase specific activity approximately parallels the nirdazole reductase activity.

TL;DR: Rat hearts took up less adenosine than guinea-pig hearts at 32°–37°, and the uptake process in rats was not blocked by dipyridamole, and a possible explanation is that the rat heart lacks the membrane-bound enzyme,Adenosine uptake depending upon a soluble kinase.

TL;DR: Of the tissues examined liver is the most active in synthesizing these three metabolites although there is some activity in lung and kidney but little or none in brain, heart, spleen or blood.

TL;DR: The action of WL 19255 differs from that of piperonyl butoxide and NIA 16824 in that it is relatively non-specific in inhibiting enzymatic activity on several substrates, gives a more prolonged effect on P-450, and the magnitude of induction is greater.

TL;DR: The four K-region epoxides were clearly much more reactive towards the constituents of both cell lines than either the parent hydrocarbons or the corresponding dihydrodiols and phenols.

TL;DR: Local denervation of rabbit corneas resulted in a decrease of 87–100 per cent of corneal epithelial acetylcholine thus suggesting a neuronal affiliation of this substance, and it is hypothesized that acetylCholine may have a role in pain perception in the cornea.

TL;DR: It is suggested that DCVC and DCVMP may interact with different components of the 2-oxoacid dehydrogenases through different groupings.

TL;DR: The effect of Ro 4-4602 varies according to differences in the affinity of the amino acids for the decarboxylase and possibly in their penetration through the blood-brain barrier, and the cerebral norepinephrine formed after administration of DOPS is mainly localized in the capillaries of the brain.

TL;DR: The agents which inhibit swelling also inhibited formation of lysolecithin and free fatty acids from mitochondria under influence of phospholipase A, and no inhibition was found when detergent-dispersed mitochondria served as substrate for the enzyme.

TL;DR: Isotopic and nonisotopic measurement of brain norepinephrine and serotonin turnover rates shows that morphine dependence fails to change these rates.

TL;DR: Studies with the partially purified erythrocytic guanylate kinase showed that GMP, dGMP, 8-azaGMP and IMP serve as substrates while UMP, CMP and 6-thioIMP do not.