Journal ArticleDOI
Inhibition of dopamine β-hydroxylase by fusaric acid (5-butylpicolinic acid) in vitro and in vivo
Nagatsu Toshiharu,Hidaka Hiroyoshi,Kuzuya Hiroshi,Takeya Kazumi,Umezawa Hamao,Takeuchi Tomio,Suda Hiroyuki +6 more
TLDR
Since dopamineβ-hydroxylase activity in adrenal medulla was found to be inhibited in vivo after the administration of fusaric acid, the decrease in the catecholamine levels is attributed to the inhibition of norepinephrine synthesis at the dopamine β-Hydroxylases stage.About:
This article is published in Biochemical Pharmacology.The article was published on 1970-01-01. It has received 149 citations till now. The article focuses on the topics: Fusaric acid & Catecholamine.read more
Citations
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The Dopamine Hypothesis of Schizophrenia: A Review*
Journal ArticleDOI
The pathophysiological response to spinal cord injury. The current status of related research.
TL;DR: This review of spinal cord injury research has placed special emphasis on the controversial issues appropriate to a new, stimulating, and competitive area of research.
Journal ArticleDOI
Influence of norepinephrine-containing neurons derived from the locus coeruleus on lateral geniculate neuronal activities of cats
Yoshihisa Nakai,Shuji Takaori +1 more
TL;DR: It is suggested from these findings that enhanced responsiveness of relay neurons is due to an inhibitory effect on type-B interneurons after activation of NE-containing neurons derived from the LC.
Journal ArticleDOI
Norepinephrine metabolism in the central nervous system of man: studies using 3-methoxy-4-hydroxyphenylethylene glycol levels in cerebrospinal fluid.
TL;DR: MHPG values in CSF may provide an index to norepinephrine metabolism in the central nervous system of man, and doses of l‐DOPA or probenecid, sufficient to substantially elevate CSF levels of the dopamine metabolite, homovanillic acid, failed to alter the spinal fluid content of MHPG.
References
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Journal Article
Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart
TL;DR: Factors indicate that conversion of tyrosine to dopa is the rate-limiting step in the formation of norepinephrine in the sympathetic nervous system and ascorbic acid has been shown to be a requirement for purified dopamine-β-oxidase activity.
Journal ArticleDOI
3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.
Stanley Friedman,Seymour Kaufman +1 more
Journal ArticleDOI
The enzymatic conversion of 3,4-dihydroxyphenylethylamine to norepinephrine.
Journal ArticleDOI
A Rapid Spectrophotometric Assay of Monoamine Oxidase Based on the Rate of Disappearance of Kynuramine
TL;DR: Intramolecular (nonenzymatic) condensation of the aminoaldehyde proved to be faster than the further oxidation of the aldehyde to the acid or lactam and has been developed into a rapid method for the assay of monoamine oxidase.
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3,4-dihydroxyphenylethylamine beta-hydroxylase. Physical properties, copper content, and role of copper in the catalytic acttivity.
Stanley Friedman,Seymour Kaufman +1 more