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Utham K. Valekunja
Researcher at University of Pennsylvania
Publications - 15
Citations - 1277
Utham K. Valekunja is an academic researcher from University of Pennsylvania. The author has contributed to research in topics: CLOCK & Circadian clock. The author has an hindex of 9, co-authored 14 publications receiving 1039 citations. Previous affiliations of Utham K. Valekunja include National Institute for Health Research & University of Cambridge.
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Journal ArticleDOI
Response to Comment on "Circadian rhythms in the absence of the clock gene Bmal1".
Sandipan Ray,Utham K. Valekunja,Alessandra Stangherlin,Steven Howell,Ambrosius P. Snijders,Gopinath Damodaran,Akhilesh B. Reddy +6 more
TL;DR: This article showed that transcriptome oscillations found in their study in the absence of Bmal1 are of low amplitude, statistical significance, and consistency, and provided statistical measures and additional analyses showing that their original analyses and observations are accurate.
Posted ContentDOI
SlumberNet: Deep learning classification of sleep stages using residual neural networks
TL;DR: In this article , a deep learning model based on residual network (ResNet) architecture was designed to classify sleep states in mice using electroencephalogram (EEG) and electromyogram (EMG) signals.
Posted ContentDOI
Clock gene-independent daily regulation of haemoglobin oxidation in red blood cells
Andrew D. Beale,Priya Crosby,Priya Crosby,Utham K. Valekunja,Rachel S. Edgar,Johanna E. Chesham,Elizabeth S. Maywood,Fatima H. Labeed,Akhilesh B. Reddy,Kenneth P. Wright,Kathryn S. Lilley,Michael H. Hastings,John S. O’Neill +12 more
TL;DR: In this article, a covalent haemoglobin-haemoglobin linkage is formed during cell lysis, which is shown to serve an important physiological role in gas transport.
Posted ContentDOI
Single-cell transcriptomics and cell-specific proteomics reveals molecular signatures of sleep
TL;DR: In this article, a combination of single cell RNA sequencing and cell-type specific proteomics was used to interrogate the molecular underpinnings of sleep in three important brain regions for sleep (brainstem, cortex, and hypothalamus).
Posted ContentDOI
Non-canonical circadian oscillations in Drosophila S2 cells drive gene-expression cycles coupled to metabolic oscillations
Guillaume Rey,Nikolay B. Milev,Utham K. Valekunja,Ratnasekhar Ch,Sandipan Ray,Mariana Silva dos Santos,András D. Nagy,Robin Antrobus,James I. MacRae,Akhilesh B. Reddy +9 more
TL;DR: It is demonstrated that daily genome-wide oscillations, coupled to metabolic cycles, take place in eukaryotic cells without the contribution of known circadian regulators.