V
V Bacote
Researcher at University of Tennessee Health Science Center
Publications - 2
Citations - 1055
V Bacote is an academic researcher from University of Tennessee Health Science Center. The author has contributed to research in topics: Glucose transporter & Desensitization (medicine). The author has an hindex of 2, co-authored 2 publications receiving 984 citations.
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Journal ArticleDOI
Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.
TL;DR: It is indicated that a unique metabolic pathway exists in adipocytes that mediates desensitization of the insulin-responsive GTS, and that an early step in this pathway involves the conversion of fructose 6-phosphate to glucosamine 6- phosphate by the first and rate-limiting enzyme of the hexosamine pathway, glutamine:fructose-6-ph phosphate amidotransferase.
Journal ArticleDOI
Complete inhibition of glucose-induced desensitization of the glucose transport system by inhibitors of mRNA synthesis. Evidence for rapid turnover of glutamine:fructose-6-phosphate amidotransferase.
TL;DR: Glutamine:fructose-6-phosphate amidotransferase (GFAT) plays a key role in desensitizing the insulin-responsive glucose transport system (GTS), and recent studies have revealed that loss of GFAT activity accompanies desensItization.