Discovery of a metabolic pathway mediating glucose-induced desensitization of the glucose transport system. Role of hexosamine biosynthesis in the induction of insulin resistance.
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TLDR
It is indicated that a unique metabolic pathway exists in adipocytes that mediates desensitization of the insulin-responsive GTS, and that an early step in this pathway involves the conversion of fructose 6-phosphate to glucosamine 6- phosphate by the first and rate-limiting enzyme of the hexosamine pathway, glutamine:fructose-6-ph phosphate amidotransferase.About:
This article is published in Journal of Biological Chemistry.The article was published on 1991-03-15 and is currently open access. It has received 971 citations till now. The article focuses on the topics: Azaserine & Insulin resistance.read more
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Biochemistry and molecular cell biology of diabetic complications
TL;DR: This integrating paradigm provides a new conceptual framework for future research and drug discovery in diabetes-specific microvascular disease and seems to reflect a single hyperglycaemia-induced process of overproduction of superoxide by the mitochondrial electron-transport chain.
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Regulation of cancer cell metabolism
TL;DR: Interest in the topic of tumour metabolism has waxed and waned over the past century, but it has become clear that many of the signalling pathways that are affected by genetic mutations and the tumour microenvironment have a profound effect on core metabolism, making this topic once again one of the most intense areas of research in cancer biology.
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Glycosylation in cancer: mechanisms and clinical implications
Salomé S. Pinho,Celso A. Reis +1 more
TL;DR: The roles of glycans are highlighted by the fact that alterations in glycosylation regulate the development and progression of cancer, serving as important biomarkers and providing a set of specific targets for therapeutic intervention.
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Role of Fatty Acids in the Pathogenesis of Insulin Resistance and NIDDM
TL;DR: Continuously elevated levels of plasma FFAs may play a key role in the pathogenesis of NIDDM in predisposed individuals by impairing peripheral glucose utilization and by promoting hepatic glucose overproduction.
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Cycling of O-linked β- N -acetylglucosamine on nucleocytoplasmic proteins
TL;DR: Emerging data indicate that O-GlcNAc glycosylation has a role in the aetiology of diabetes and neurodegeneration.
References
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Metabolism of isolated fat cells. i. effects of hormones on glucose metabolism and lipolysis.
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Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage site
Kazuo Suzuki,Tetsuro Kono +1 more
TL;DR: Results imply that insulin facilitates translocation of the transport activity from an intracellular storage site to the plasma membrane, and this results imply that glucose transport facilitated by the activities in peaks A and B is facilitated.
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TL;DR: Textbook of biochemistry: with clinical correlations, Textbook of bioinformatics: withclinical correlations, and more.
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Insulin resistance, insulin insensitivity, and insulin unresponsiveness ; a necessary distinction
TL;DR: With more precise use of these terms and a more complete understanding of insulin action, it will be possible to begin to segregate the roles of the various prereceptor, receptor and postreceptor factors that are involved in producing the differing patterns of metabolism observed in disease.
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