V. Reale

TL;DR: Amino-acid sequences derived from complementary DMAs encoding the α- and β-subunits of the GAB A/ benzo diazepine receptor from bovine brain show homology with other ligand-gated receptor subunits, suggesting that there is a super-family of ion-channel-containing receptors.

TL;DR: From this network of interactions, it can be deduced that several of these sites can be occupied by their respective ligands simultaneously and that each of the 5 or more types of site must be physically separate on the receptor structure.

TL;DR: Examination of the nucleotide specificity of channel inhibition indicates a high selectivity for AMP over the other nucleotides tested with a rank order of potency of AMP > UMP > CMP ≥GMP, with cyclic UMP being almost equipotent withcyclic AMP.

TL;DR: The regulation of a calcium-activated nonselective cation (Ca-NS+) channel by analogues of cyclic AMP has been investigated in the rat insulinoma cell line, CRI-G1, and results are discussed in terms of a model in which cyclicAMP, and other cyclic nucleotides, modulate the activity of the Ca-NS+ channel by binding to two separate sites.

TL;DR: The application of β-NAD+, but not of the other nucleotides tested, to the cytoplasmic surface of isolated inside-out patches from CRI-G1 cells opened a novel nonselective cation channel (the β- NAD+-NS+ channel), which is calcium sensitive and may also be inhibited by AMP.