V
Valentin Gorboulev
Researcher at University of Würzburg
Publications - 57
Citations - 5480
Valentin Gorboulev is an academic researcher from University of Würzburg. The author has contributed to research in topics: Organic cation transport proteins & Cotransporter. The author has an hindex of 34, co-authored 57 publications receiving 5128 citations. Previous affiliations of Valentin Gorboulev include Goethe University Frankfurt & University of Göttingen.
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Journal ArticleDOI
Drug excretion mediated by a new prototype of polyspecific transporter
TL;DR: The isolation of a complementary DNA from rat kidney is reported that encodes a 556-amino-acid membrane protein, OCT1, which has the functional characteristics of organic cation uptake over the basolateral membrane of renal proximal tubules and of organiccation uptake into hepatocytes.
Journal ArticleDOI
Cloning and Characterization of Two Human Polyspecific Organic Cation Transporters
Valentin Gorboulev,Jochen C. Ulzheimer,Aida Akhoundova,Isabel Ulzheimer-Teuber,Ulrich Karbach,Sven Quester,Carmen Baumann,Florian Lang,Andreas Busch,Hermann Koepsell +9 more
TL;DR: Cl cloning and characterization of two homologous transporters from man (hOCT1 and hOCT2) displaying approximately 80% amino acid identity to rOCT 1 and rO CT2 are reported, respectively.
Journal ArticleDOI
Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose-Absorption and Glucose-Dependent Incretin Secretion
Valentin Gorboulev,Annette Schürmann,Volker Vallon,Helmut Kipp,Alexander Jaschke,Dirk Klessen,Alexandra Friedrich,Stephan Scherneck,Timo Rieg,Robyn Cunard,Maike Veyhl-Wichmann,Aruna Srinivasan,Daniela Balen,Davorka Breljak,Rexhep Rexhepaj,Helen E. Parker,Fiona M. Gribble,Frank Reimann,Florian Lang,Stefan Wiese,Ivan Sabolić,Michael Sendtner,Hermann Koepsell +22 more
TL;DR: In this article, the role of SGLT1 in small intestine and kidney glucose absorption was investigated in Sglt1(-/-) mice, which developed a glucose-galactose malabsorption syndrome.
Journal ArticleDOI
A glucose sensor hiding in a family of transporters.
Ana Díez-Sampedro,Bruce A. Hirayama,Christina Osswald,Valentin Gorboulev,Katharina Baumgarten,Christopher Volk,Ernest M. Wright,Hermann Koepsell +7 more
TL;DR: It is suggested that SGLT3 is not a Na+/glucose cotransporter but instead a glucose sensor in the plasma membrane of cholinergic neurons, skeletal muscle, and other tissues, and points to an unexpected role of glucose and SLC5 proteins in physiology.
Book ChapterDOI
Organic cation transporters.
TL;DR: This review provides a survey of cloned organic cation transporters and tentative models that illustrate how different types of organic cations, expressed at specific subcellular sites in hepatocytes and renal proximal tubular cells, are assembled into an integrated functional framework.