R
Robyn Cunard
Researcher at Veterans Health Administration
Publications - 36
Citations - 2977
Robyn Cunard is an academic researcher from Veterans Health Administration. The author has contributed to research in topics: Peroxisome proliferator-activated receptor & Kidney. The author has an hindex of 22, co-authored 32 publications receiving 2596 citations. Previous affiliations of Robyn Cunard include University of California, Los Angeles & University of California, San Diego.
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Journal ArticleDOI
Na+-D-glucose Cotransporter SGLT1 is Pivotal for Intestinal Glucose-Absorption and Glucose-Dependent Incretin Secretion
Valentin Gorboulev,Annette Schürmann,Volker Vallon,Helmut Kipp,Alexander Jaschke,Dirk Klessen,Alexandra Friedrich,Stephan Scherneck,Timo Rieg,Robyn Cunard,Maike Veyhl-Wichmann,Aruna Srinivasan,Daniela Balen,Davorka Breljak,Rexhep Rexhepaj,Helen E. Parker,Fiona M. Gribble,Frank Reimann,Florian Lang,Stefan Wiese,Ivan Sabolić,Michael Sendtner,Hermann Koepsell +22 more
TL;DR: In this article, the role of SGLT1 in small intestine and kidney glucose absorption was investigated in Sglt1(-/-) mice, which developed a glucose-galactose malabsorption syndrome.
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SGLT2 Mediates Glucose Reabsorption in the Early Proximal Tubule
Volker Vallon,Kenneth A. Platt,Robyn Cunard,Jana Schroth,Jean M. Whaley,Scott C. Thomson,Hermann Koepsell,Timo Rieg +7 more
TL;DR: It is demonstrated that SGLT2 mediates glucose re absorption in the early proximal tubule and most of the glucose reabsorption by the kidney, overall, which mimics and explains the glucosuric phenotype of individuals carrying SLC5A2 mutations.
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Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus
Volker Vallon,Volker Vallon,Michael Rose,Maria Gerasimova,Joseph Satriano,Joseph Satriano,Kenneth A. Platt,Hermann Koepsell,Robyn Cunard,Robyn Cunard,Kumar Sharma,Kumar Sharma,Scott C. Thomson,Scott C. Thomson,Timo Rieg,Timo Rieg +15 more
TL;DR: The results indicate that SGLT2 is a determinant of hyperglycemia and glomerular hyperfiltration in STZ-induced diabetes mellitus but is not critical for the induction of renal growth and markers of renal injury, inflammation, and fibrosis.
Journal ArticleDOI
Regulation of Cytokine Expression by Ligands of Peroxisome Proliferator Activated Receptors
Robyn Cunard,Mercedes Ricote,Dennis DiCampli,D. Clay Archer,Daniel Kahn,Christopher K. Glass,Carolyn J. Kelly,Carolyn J. Kelly +7 more
TL;DR: These findings support the roles of PPAR ligands in modulating inflammatory responses involving lymphocytes but also establish potent effects of the fibrate class of PParα ligands on IL-4 expression that are receptor independent.
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Immunotoxicity of perfluorooctanoic acid and perfluorooctane sulfonate and the role of peroxisome proliferator-activated receptor alpha.
Jamie C. DeWitt,Alexander Shnyra,Mostafa Z. Badr,Scott E. Loveless,Denise Hoban,Steven R. Frame,Robyn Cunard,Stacey E. Anderson,B. Jean Meade,Margie M. Peden-Adams,Robert W. Luebke,Michael I. Luster +11 more
TL;DR: Current and recently published work exploring immunomodulation by PFOA and PFOS are described, and potential PPARα independence indicates that future research must explore mechanisms of action of these compounds, including PPAR α -dependent and -independent pathways.