Valéria Rêgo Alves Pereira

TL;DR: The knowledge about this responses based on the prevailing cytokine profile can help to elucidate the immune response related to the protection against M. tuberculosis, as well as support the survival of mycobacteria in the host.

TL;DR: In this article, the authors evaluated the mechanism associated with cytotoxic activity displayed by the drug 5-fluorouracil incorporated in Cu-BTC MOF and its slow delivery from the Cu-bitcoin MOF.

TL;DR: The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking studies of a novel series of 2-(pyridin-2-yl)-1,3-thiazoles derived from 2-pyridine thiosemicarbazone, which are potent cruzain inhibitors and showed excellent inhibition on the trypomastigote form of the parasite.

TL;DR: In this paper, the authors bring classical and current information about technological advances for the immunological and molecular leishmaniases diagnosis, their features, and applications, as well as their potential to clarify and minimize the present global situation of the diseases.

TL;DR: One high-efficacy trypanocidal compound was able to be identified, 2-minothiazolidin-4-one 18, which inhibited the activity of cruzain and the proliferation of epimastigotes and was cidal for trypomastigote but was not toxic for splenocytes.