D
Diogo Rodrigo Magalhães Moreira
Researcher at Oswaldo Cruz Foundation
Publications - 96
Citations - 2785
Diogo Rodrigo Magalhães Moreira is an academic researcher from Oswaldo Cruz Foundation. The author has contributed to research in topics: Trypanosoma cruzi & Benznidazole. The author has an hindex of 27, co-authored 88 publications receiving 2192 citations. Previous affiliations of Diogo Rodrigo Magalhães Moreira include Federal University of Pernambuco & Centro Hospitalar de Vila Nova de Gaia/Espinho.
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Journal ArticleDOI
Halogen atoms in the modern medicinal chemistry: hints for the drug design.
Marcelo Zaldini Hernandes,Suellen Melo Tibúrcio Cavalcanti,Diogo Rodrigo Magalhães Moreira,Walter Filgueira de Azevedo Junior,Ana Cristina Lima Leite +4 more
TL;DR: This review serves as one guide for the virtual screening of libraries containing halogenated drugs and their structural and pharmacological features and may be a source of inspiration for the medicinal chemists.
Journal ArticleDOI
Synthesis, docking, and in vitro activity of thiosemicarbazones, aminoacyl-thiosemicarbazides and acyl-thiazolidones against Trypanosoma cruzi
Ana Cristina Lima Leite,Renata Souza de Lima,Diogo Rodrigo Magalhães Moreira,Marcos Veríssimo de Oliveira Cardoso,Ana Carolina Gouveia de Brito,Luciene Maria F. Santos,Marcelo Zaldini Hernandes,Alice Costa Kiperstok,Ricardo Lima,Milena Botelho Pereira Soares +9 more
TL;DR: Docking studies were carried out in order to investigate the binding pattern of these compounds for the T. cruzi cruzain (TCC) protein, and these showed a significant correlation with experimental data.
Journal ArticleDOI
Design, synthesis and cruzain docking of 3-(4-substituted-aryl)-1,2,4-oxadiazole-N-acylhydrazones as anti-Trypanosoma cruzi agents
José Maurício dos Santos Filho,Ana Cristina Lima Leite,Boaz G. Oliveira,Diogo Rodrigo Magalhães Moreira,Milena S. Lima,Milena Botelho Pereira Soares,Milena Botelho Pereira Soares,Lúcia Fernanda C. da Costa Leite +7 more
TL;DR: The series of compounds based on the 3-(4-substituted-aryl)-1,2,4-oxadiazole scaffold revealed the remarkable importance of each substituent at the phenyl's 4-position for the inhibitory activity.
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2-Pyridyl thiazoles as novel anti-Trypanosoma cruzi agents: structural design, synthesis and pharmacological evaluation
Marcos Veríssimo de Oliveira Cardoso,Lucianna Rabelo Pessoa de Siqueira,Elany Barbosa da Silva,Lívia Bandeira Costa,Marcelo Zaldini Hernandes,Marcelo M. Rabello,Rafaela Salgado Ferreira,Luana Faria da Cruz,Diogo Rodrigo Magalhães Moreira,Valéria Rêgo Alves Pereira,Maria Carolina Accioly Brelaz de Castro,Paul V. Bernhardt,Ana Cristina Lima Leite +12 more
TL;DR: The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking studies of a novel series of 2-(pyridin-2-yl)-1,3-thiazoles derived from 2-pyridine thiosemicarbazone, which are potent cruzain inhibitors and showed excellent inhibition on the trypomastigote form of the parasite.
Journal ArticleDOI
Artemisinin-(Iso)quinoline Hybrids by C-H Activation and Click Chemistry: Combating Multidrug-Resistant Malaria.
Aysun Çapcı,Mélanie M. Lorion,Hui Wang,Nina Simon,Maria Leidenberger,Mariana C. Borges Silva,Diogo Rodrigo Magalhães Moreira,Yongping Zhu,Yuqing Meng,Jia Yun Chen,Yew Mun Lee,Oliver Friedrich,Barbara Kappes,Jigang Wang,Lutz Ackermann,Svetlana B. Tsogoeva +15 more
TL;DR: Through chemical proteomics, putatively hybrid‐binding protein targets of the ART‐quinolines were successfully identified in addition to known targets of quinoline and artemisinin alone, suggesting that the hybrids act through multiple modes of action to overcome resistance.