V
Valérie Van der Eecken
Researcher at Université catholique de Louvain
Publications - 5
Citations - 350
Valérie Van der Eecken is an academic researcher from Université catholique de Louvain. The author has contributed to research in topics: Peroxiredoxin & PRDX5. The author has an hindex of 4, co-authored 5 publications receiving 311 citations.
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Journal ArticleDOI
Peroxiredoxin 5: Structure, Mechanism, and Function of the Mammalian Atypical 2-Cys Peroxiredoxin
TL;DR: Mammalian PRDX5 appears to be a unique peroxiredoxin exhibiting specific functional and structural features, and crystal structures confirmed the proposed enzymatic mechanisms based on biochemical data but revealed also some specific unexpected structural features.
Book ChapterDOI
Evolution of the peroxiredoxins.
TL;DR: Peroxiredoxins compose a superfamily of peroxidases ubiquitously found throughout evolution in prokaryotes, archaea and eukaryotes and may have evolved to a modulatory role in hydrogen peroxide signaling in plants and animals.
Journal ArticleDOI
Human peroxiredoxin 5 gene organization, initial characterization of its promoter and identification of alternative forms of mRNA.
Nhu Tiên Nguyên-nhu,Jehanne Berck,André Clippe,Elee Duconseille,H. Cherif,C Boone,Valérie Van der Eecken,Alfred Bernard,Ingrid Banmeyer,Bernard Knoops +9 more
TL;DR: The characterization of human PRDX5 gene revealed the complexity of its regulation and a high variability of sequences that might be associated with pathological situations.
Journal ArticleDOI
Mitochondrial targeting of peroxiredoxin 5 is preserved from annelids to mammals but is absent in pig Sus scrofa domesticus.
TL;DR: It appears that mitochondrial targeting of PRDX5 may have been lost throughout evolution in animal species, including pig, with unknown functional consequences.
Journal ArticleDOI
Abolition of Peroxiredoxin-5 Mitochondrial Targeting during Canid Evolution
Valérie Van der Eecken,André Clippe,Sophie Dekoninck,Julie Goemaere,Geoffroy Walbrecq,Paul P. Van Veldhoven,Bernard Knoops +6 more
TL;DR: Although mitochondrial PRDX5 cytoprotective function against oxidative stress has been clearly demonstrated in human and rodents,PRDX5 targeting to mitochondria has been evolutionary lost in canids.