V
Valerio Pazienza
Researcher at Casa Sollievo della Sofferenza
Publications - 137
Citations - 5036
Valerio Pazienza is an academic researcher from Casa Sollievo della Sofferenza. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 36, co-authored 124 publications receiving 4100 citations. Previous affiliations of Valerio Pazienza include University of Geneva & University of Foggia.
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Journal ArticleDOI
Relationship Between Steatosis, Inflammation, and Fibrosis in Chronic Hepatitis C: A Meta-Analysis of Individual Patient Data
Gioacchino Leandro,Alessandra Mangia,Jason M. Hui,Paolo Fabris,Laura Rubbia Brandt,Guido Colloredo,Luigi Elio Adinolfi,Tarik Asselah,Julie R. Jonsson,Antonina Smedile,Norah A. Terrault,Valerio Pazienza,Maria Teresa Giordani,Emiliano Giostra,Aurelio Sonzogni,Giuseppe Ruggiero,Patrick Marcellin,Elizabeth E. Powell,Jacob George,Francesco Negro +19 more
TL;DR: In this large and geographically different group of CHC patients, steatosis is confirmed as significantly and independently associated with fibrosis in CHC.
Journal ArticleDOI
The hepatitis C virus core protein of genotypes 3a and 1b downregulates insulin receptor substrate 1 through genotype-specific mechanisms.
Valerio Pazienza,Sophie Clément,Paolo Pugnale,Stéphanie Conzelman,Michelangelo Foti,Alessandra Mangia,Francesco Negro +6 more
TL;DR: Despite the small sequence divergence of the HCV core proteins of genotypes 3a and 1b, the 2 proteins appear to interfere with the insulin signaling pathway using genotype‐specific mechanisms.
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Pharmacomicrobiomics: exploiting the drug-microbiota interactions in anticancer therapies.
TL;DR: The use of probiotics, prebiotic, synbiotics, postbiotics and antibiotics are discussed as emerging strategies for manipulating the microbiota in order to improve therapeutic outcome or at least ensure patients a better quality of life all along of anticancer treatments.
Journal ArticleDOI
An in vitro model of hepatitis C virus genotype 3a-associated triglycerides accumulation.
Karim Abid,Valerio Pazienza,Andrea De Gottardi,Laura Rubbia-Brandt,Béatrice Conne,Paolo Pugnale,Christine Rossi,Alessandra Mangia,Francesco Negro +8 more
TL;DR: In vitro expression of HCV genotype 3a core protein is the ideal candidate model for studying the mechanisms ofHCV-associated steatosis and is consistent with observations in chronic hepatitis C patients.
Journal ArticleDOI
Mirna expression profiles identify drivers in colorectal and pancreatic cancers.
Ada Piepoli,Francesca Tavano,Massimiliano Copetti,Tommaso Mazza,Orazio Palumbo,Anna Panza,Francesco Fabio di Mola,Valerio Pazienza,Gianluigi Mazzoccoli,Giuseppe Biscaglia,Annamaria Gentile,Nicola Mastrodonato,Massimo Carella,Fabio Pellegrini,Pierluigi Di Sebastiano,Angelo Andriulli +15 more
TL;DR: MiRNA expression profiles may identify cancer-specific signatures and potentially useful biomarkers for the diagnosis of tissue specific cancers and miRNA-network analysis help identify altered miRNA regulatory networks that could play a role in tumor pathogenesis.