V
Valery V. Fokin
Researcher at University of Southern California
Publications - 184
Citations - 36801
Valery V. Fokin is an academic researcher from University of Southern California. The author has contributed to research in topics: Cycloaddition & Catalysis. The author has an hindex of 67, co-authored 181 publications receiving 34132 citations. Previous affiliations of Valery V. Fokin include University of Illinois at Chicago & QIMR Berghofer Medical Research Institute.
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Journal ArticleDOI
A stepwise huisgen cycloaddition process: copper(I)-catalyzed regioselective "ligation" of azides and terminal alkynes.
Journal ArticleDOI
Copper-catalyzed azide–alkyne cycloaddition (CuAAC) and beyond: new reactivity of copper(I) acetylides
Jason E. Hein,Valery V. Fokin +1 more
TL;DR: This tutorial review examines the history of the development of the CuAAC reaction, its key mechanistic aspects, and highlights the features that make it useful to practitioners in different fields of chemical science.
Journal ArticleDOI
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
TL;DR: The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently in aqueous solution in the presence of a tris(triazolyl)amine ligand to make rapid and reliable covalent connections to micromolar concentrations of protein decorated with either of the reactive moieties.
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Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates.
Fahmi Himo,Timothy Lovell,Robert Hilgraf,Vsevolod V. Rostovtsev,Louis Noodleman,K. Barry Sharpless,Valery V. Fokin +6 more
TL;DR: Huisgen's 1,3-dipolar cycloadditions become nonconcerted when copper(I) acetylides react with azides and nitrile oxides, providing ready access to 1,4-disubstituted 1,2, 3-triazoles and 3, 4-disubsided isoxazoles, respectively.
Journal ArticleDOI
“On Water”: Unique Reactivity of Organic Compounds in Aqueous Suspension
TL;DR: This workFloat their problematic reactions on water and to send observations of success or failure to us at onwater@scripps.edu for public dissemination with attribution.