R
Robert Hilgraf
Researcher at Scripps Research Institute
Publications - 8
Citations - 4576
Robert Hilgraf is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Catalysis & Disproportionation. The author has an hindex of 5, co-authored 7 publications receiving 4316 citations. Previous affiliations of Robert Hilgraf include Celgene.
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Journal ArticleDOI
Bioconjugation by Copper(I)-Catalyzed Azide-Alkyne [3 + 2] Cycloaddition
TL;DR: The copper-catalyzed cycloaddition reaction between azides and alkynes functions efficiently in aqueous solution in the presence of a tris(triazolyl)amine ligand to make rapid and reliable covalent connections to micromolar concentrations of protein decorated with either of the reactive moieties.
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Copper(I)-catalyzed synthesis of azoles. DFT study predicts unprecedented reactivity and intermediates.
Fahmi Himo,Timothy Lovell,Robert Hilgraf,Vsevolod V. Rostovtsev,Louis Noodleman,K. Barry Sharpless,Valery V. Fokin +6 more
TL;DR: Huisgen's 1,3-dipolar cycloadditions become nonconcerted when copper(I) acetylides react with azides and nitrile oxides, providing ready access to 1,4-disubstituted 1,2, 3-triazoles and 3, 4-disubsided isoxazoles, respectively.
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Polytriazoles as copper(I)-stabilizing ligands in catalysis.
TL;DR: The C3-symmetric derivative of polytriazolylamines, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity.
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Polytriazoles as Copper(I)‐Stabilizing Ligands in Catalysis.
TL;DR: The C3-symmetric derivative, TBTA, was shown to be a powerful stabilizing ligand for copper(I), protecting it from oxidation and disproportionation, while enhancing its catalytic activity as mentioned in this paper.
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Osmium-Catalyzed Olefin Dihydroxylation and Aminohydroxylation in the Second Catalytic Cycle
TL;DR: In this paper, a series of new chelating ligands were devised to force the catalysis into the second cycle while maintaining enantiocontrol in the olefin addition step.