Vanessa M. Thompson

TL;DR: Intracisternal administration of mifepristone, a GR antagonist, effectively reduced immune-activated proinflammatory responses, specifically from hippocampal microglia and prevented Escherichia coli-induced memory impairments in aged rats, and voluntary exercise as a therapeutic intervention significantly reduced total hippocampal GR expression.

TL;DR: Evidence at a molecular level is provided for the involvement of the hippocampus and BLA in the retrieval of spatial memory and novel observations on the influence of pre-training stress in activating the DLS in response to long-term memory retrieval are contributed.

TL;DR: The presence of glucocorticoids may constrain Mkp1 gene expression in the neural forebrain and endocrine tissues, and this possible constraint may be an indirect consequence of the inhibitory influence of glucOCorticoid on stress-induced activation of ERK1/2, a known upstream positive regulator of Mkp 1 gene transcription.

TL;DR: The results suggest that renal-selective edaravone delivery holds potential for the prevention of acute kidney injury among patients undergoing cisplatin-based chemotherapy.

TL;DR: The data strongly suggest that hepatic and splenic macrophages do not play a major role in the long-lasting maintenance of the proinflammatory response in the hippocampus of aged rats following a bacterial infection, or the memory declines that this response produces.