V
Vangala Santhosh Reddy
Researcher at Indian Institute of Chemical Technology
Publications - 17
Citations - 352
Vangala Santhosh Reddy is an academic researcher from Indian Institute of Chemical Technology. The author has contributed to research in topics: Tubulin & Cancer. The author has an hindex of 11, co-authored 17 publications receiving 301 citations. Previous affiliations of Vangala Santhosh Reddy include Council of Scientific and Industrial Research.
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Journal ArticleDOI
Synthesis of β-carboline–benzimidazole conjugates using lanthanum nitrate as a catalyst and their biological evaluation
Ahmed Kamal,M. P. Narasimha Rao,P. Swapna,Vunnam Srinivasulu,Chandrakant Bagul,Anver Basha Shaik,Kishore Mullagiri,Jeshma Kovvuri,Vangala Santhosh Reddy,K. Vidyasagar,Narayana Nagesh +10 more
TL;DR: An in silico study of these β-carboline-benzimidazole conjugates reveals that they possess drug-like properties and substantiate the cytotoxic activity and the nature of interaction of these conjugate with DNA.
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Synthesis of phenstatin/isocombretastatin–chalcone conjugates as potent tubulin polymerization inhibitors and mitochondrial apoptotic inducers
Ahmed Kamal,G. Bharath Kumar,M.V.P.S. Vishnuvardhan,Anver Basha Shaik,Vangala Santhosh Reddy,Rasala Mahesh,Ibrahim Bin Sayeeda,Jeevak Sopanrao Kapure +7 more
TL;DR: A series of phenstatin/isocombretastatin–chalcones synthesized and screened for their cytotoxic activity against various human cancer cell lines showed a broad spectrum of antiproliferative efficacy on most of the cell lines in the sub-micromolar range.
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Synthesis of arylpyrazole linked benzimidazole conjugates as potential microtubule disruptors.
Ahmed Kamal,Anver Basha Shaik,Sowjanya Polepalli,G. Bharath Kumar,Vangala Santhosh Reddy,Rasala Mahesh,Srujana Garimella,Nishant Jain +7 more
TL;DR: Investigations reveal that such conjugates having pyrazole and benzimidazole moieties have the potential in the development of newer chemotherapeutic agents.
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Design, synthesis and biological evaluation of imidazopyridine/imidazopyrimidine-benzimidazole conjugates as potential anticancer agents
Ahmed Kamal,G. Bharath Kumar,V. Lakshma Nayak,Vangala Santhosh Reddy,Anver Basha Shaik,Rajender,M. Kashi Reddy +6 more
TL;DR: The present study demonstrates that the synthesis of imidazopyridine/imidZopyrimidine-benzimidazole conjugates as promising tubulin inhibitors with G2/M phasecell cycle arrest and apoptotic-inducing ability.
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Synthesis and Biological Evaluation of Imidazopyridine–Oxindole Conjugates as Microtubule‐Targeting Agents
Ahmed Kamal,Vangala Santhosh Reddy,Santosh Karnewar,Sumit S. Chourasiya,Anver Basha Shaik,G. Bharath Kumar,Chandan Kishor,M. Kashi Reddy,M. P. Narasimha Rao,Ananthamurthy Nagabhushana,Ananthamurthy Nagabhushana,Kallaganti V. S. Ramakrishna,Anthony Addlagatta,Srigiridhar Kotamraju +13 more
TL;DR: Flow cytometric analysis showed that MCF‐7 cells treated by these compounds arrested in the G2/M phase of the cell cycle in a concentration‐dependent manner, and docking of compound 10 f with tubulin protein suggested that the imidazo[1,2‐a]pyridine moiety occupies the colchicine binding site of tubulin.