Rajender

TL;DR: This study illustrates the importance of introducing fluoro substitution at the C2-position apart from the incorporation of a piperazine ring in between the alkyloxy linker for enhancement of the DNA-binding ability in comparison to DSB-120 and SJG-136.

TL;DR: Compounds 3t and 3ad are the most promising candidates amongst the series and has the potential to be taken up for further detailed studies either alone or in combination with the existing therapies.

TL;DR: The present study demonstrates that the synthesis of imidazopyridine/imidZopyrimidine-benzimidazole conjugates as promising tubulin inhibitors with G2/M phasecell cycle arrest and apoptotic-inducing ability.

TL;DR: Interestingly, compounds 5b and 6b have been identified as a new class of inhibitors of tubulin polymerization and their action has been rationalized by the cell cycle arrest in G0 and G2/M phase.

TL;DR: A library of new aryl‐substituted naphthalene C8‐linked pyrrolo[2,1‐c][1,4]benzodiazepine (PBD) conjugates with various linker architectures with anticancer potential were designed, synthesized, and evaluated for their anticancer activity against a panel of 11 human cancer cell lines.