V
Vanthea Nhem
Researcher at Janssen Pharmaceutica
Publications - 4
Citations - 127
Vanthea Nhem is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Metabotropic glutamate receptor 2 & Metabotropic glutamate receptor 5. The author has an hindex of 4, co-authored 4 publications receiving 125 citations.
Papers
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Journal ArticleDOI
Discovery of 1,5-Disubstituted Pyridones: A New Class of Positive Allosteric Modulators of the Metabotropic Glutamate 2 Receptor
José María Cid,Guillaume Albert Jacques Duvey,Philippe Cluzeau,Vanthea Nhem,Karim Macary,Alexandre Raux,Nicolas Poirier,Jessica Muller,Christelle Boléa,Terry Patrick Finn,Sonia Poli,Mark Epping-Jordan,Emilie Chamelot,Francis Derouet,Francoise Girard,Gregor James Macdonald,Juan Antonio Vega,Ana Isabel de Lucas,Encarnación Matesanz,Hilde Lavreysen,María Lourdes Linares,Daniel Oehlrich,Julen Oyarzabal,Gary Tresadern,Andrés A. Trabanco,José Ignacio Andrés,Emmanuel Le Poul,Hassan Julien Imogai,Robert Johannes Lütjens,Jean-Philippe Rocher +29 more
TL;DR: In this paper, the discovery and characterization of compound 48, a selective and in vivo active mGlu2 receptor positive allosteric modulator (PAM), is described.
Patent
1, 4-disubstituted 3-cyano-pyridone derivatives and their use as positive allosteric modulators of MGLUR2-receptors
Hassan Julien Imogai,José Maria Cid-Núñez,Jose Ignacio Andres-Gil,Andrés Avelino Trabanco-Suárez,Julen Oyarzabal Santamarina,Frank Matthias Dautzenberg,Gregor James Macdonald,Shriley Elizabeth Pullan,Robert Johannes Lütjens,Guillaume Albert Jacques Duvey,Vanthea Nhem,Terry Patrick Finn,Gagik Melikyan +12 more
TL;DR: Pyridinone as mentioned in this paper is a positive allosteric modulator of metabotropic receptors -sub-type 2 ("mGluR2") which is useful for the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction.
Journal ArticleDOI
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2): Identification and synthesis of N-propyl-8-chloro-6-substituted isoquinolones
Andrés A. Trabanco,Guillaume Albert Jacques Duvey,José María Cid,Gregor James Macdonald,Philippe Cluzeau,Vanthea Nhem,Rocco Furnari,Nadia Behaj,Géraldine Poulain,Terry Patrick Finn,Hilde Lavreysen,Sonia Poli,Alexandre Raux,Yves Thollon,Nicolas Poirier,David D’Addona,José Ignacio Andrés,Robert Johannes Lütjens,Emmanuel Le Poul,Hassan Julien Imogai,Jean-Philippe Rocher +20 more
TL;DR: A series of N-propyl-8-chloro-6-substituted isoquinolones was identified as positive allosteric modulators of metabotropic glutamate receptor 2 via high throughput screening (HTS).
Journal ArticleDOI
New positive allosteric modulators of the metabotropic glutamate receptor 2 (mGluR2). Identification and synthesis of N-propyl-5-substituted isoquinolones
Andrés A. Trabanco,Guillaume Albert Jacques Duvey,José María Cid,Gregor James Macdonald,Philippe Cluzeau,Vanthea Nhem,Rocco Furnari,Nadia Behaj,Géraldine Poulain,Terry Patrick Finn,Sonia Poli,Hilde Lavreysen,Alexandre Raux,Yves Thollon,Nicolas Poirier,David D’Addona,José Ignacio Andrés,Robert Johannes Lütjens,Emmanuel Le Poul,Hassan Julien Imogai,Jean-Philippe Rocher +20 more
TL;DR: The subsequent synthesis and preliminary SAR exploration that led to the identification of compound 20 are described, which was identified as positive allosteric modulators of metabotropic glutamate receptor 2 via high-throughput screening.