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Emmanuel Le Poul
Researcher at Janssen Pharmaceutica
Publications - 32
Citations - 5079
Emmanuel Le Poul is an academic researcher from Janssen Pharmaceutica. The author has contributed to research in topics: Receptor & Ligand (biochemistry). The author has an hindex of 18, co-authored 32 publications receiving 4598 citations. Previous affiliations of Emmanuel Le Poul include Université libre de Bruxelles.
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Journal ArticleDOI
The metastasis suppressor gene KiSS-1 encodes kisspeptins, the natural ligands of the orphan G protein-coupled receptor GPR54.
Masato Kotani,Michel Detheux,Ann Vandenbogaerde,David Communi,Jean-Marie Vanderwinden,Emmanuel Le Poul,Stéphane Brézillon,Richard Tyldesley,Nathalie Suarez-Huerta,Fabrice Vandeput,Cédric Blanpain,Serge N. Schiffmann,Gilbert Vassart,Marc Parmentier +13 more
TL;DR: Stimulation of oxytocin secretion after kisspeptin administration to rats confirmed this hypothesis that human GPR54 was highly expressed in placenta, pituitary, pancreas, and spinal cord, suggesting a role in the regulation of endocrine function.
Journal ArticleDOI
Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation.
Emmanuel Le Poul,Cecile Loison,Sofie Struyf,Jean-Yves Springael,Vincent Lannoy,Marie-Eve Decobecq,Stéphane Brézillon,Vincent Dupriez,Gilbert Vassart,Jozef Van Damme,Marc Parmentier,Michel Detheux +11 more
TL;DR: The pharmacology of GPR43 matches indeed the effects of SCFAs on neutrophils, in terms of intracellular Ca2+ release and chemotaxis, and might constitute a target allowing us to modulate immune responses in these pathological situations.
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Specific recruitment of antigen-presenting cells by chemerin, a novel processed ligand from human inflammatory fluids.
Valérie Wittamer,Jean-Denis Franssen,Marisa Vulcano,Jean François Mirjolet,Emmanuel Le Poul,Isabelle Migeotte,Stéphane Brézillon,Richard Tyldesley,Cédric Blanpain,Michel Detheux,Alberto Mantovani,Alberto Mantovani,Silvano Sozzani,Silvano Sozzani,Gilbert Vassart,Marc Parmentier,David Communi +16 more
TL;DR: Chemerin appears as a potent chemoattractant protein of a novel class, which requires proteolytic activation and is specific for APCs, and was shown to promote calcium mobilization and chemotaxis of immature DCs and macrophages in a ChemR23-dependent manner.
Journal ArticleDOI
Pharmacological Characterization of the Human P2Y13 Receptor
Frédéric Marteau,Emmanuel Le Poul,David Communi,Didier Communi,Catherine Labouret,Pierre Savi,Jean-Marie Boeynaems,Nathalie Suarez Gonzalez +7 more
TL;DR: 2MeSADP was more potent than ADP in displacing [33P]2-methylthio-ADP bound to 1321N1 cells and increasing GTPgamma[35S] binding to membranes prepared from the same cells, which cannot be explained by differences in degradation rate.
Journal ArticleDOI
Multiple Active States and Oligomerization of CCR5 Revealed by Functional Properties of Monoclonal Antibodies
Cédric Blanpain,Jean-Marie Vanderwinden,Josef Cihak,Valérie Wittamer,Emmanuel Le Poul,Hassan Issafras,Manfred Stangassinger,Gilbert Vassart,Stefano Marullo,Detlef Schlo∸ndorff,Marc Parmentier,Matthias Mack +11 more
TL;DR: The results suggest the existence of multiple active conformations of CCR5 and indicate that C CR5 oligomers are involved in an internalization process that is distinct from that induced by the receptor's agonists.