Varun K Phadke

TL;DR: The phase 1, dose-escalation, open-label trial of a messenger RNA vaccine, mRNA-1273, which encodes the stabilized prefusion SARS-CoV-2 spike protein in healthy adults found it induced higher binding- and neutralizing-antibody titers than the 25-μg dose, which supports the use of the 100- μg dose in a phase 3 vaccine trial.

TL;DR: A substantial proportion of the US measles cases in the era after elimination were intentionally unvaccinated, and the phenomenon of vaccine refusal was associated with an increased risk for measles among people who refuse vaccines and among fully vaccinated individuals.

TL;DR: Although all contemporary aP and wP formulations protect against pertussis disease, in this meta-analysis the point estimate for short-term protective effect against WHO-defined pertussi in young children was lower for currently available aP vaccines than wP vaccines.

TL;DR: In this study, statin therapy was associated with reduced influenza VE against MAARI, a retrospective cohort study over nine influenza seasons using research databases of a large managed care organization in the United States.

TL;DR: This case highlights several characteristic features of this infection, including isolation of a nonpigmented strain of the organism, an antibiotic susceptibility profile suggestive of AmpC &bgr;-lactamase production, and rapid clinical deterioration with multiple embolic complications resulting in death.