P
Phillip A. Swanson
Researcher at National Institutes of Health
Publications - 22
Citations - 5294
Phillip A. Swanson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: CD8 & Cytotoxic T cell. The author has an hindex of 13, co-authored 20 publications receiving 3286 citations. Previous affiliations of Phillip A. Swanson include Emory University & Government of the United States of America.
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Journal ArticleDOI
An mRNA Vaccine against SARS-CoV-2 — Preliminary Report
Lisa A. Jackson,Evan J. Anderson,Nadine Rouphael,Paul C. Roberts,Mamodikoe Makhene,Rhea N. Coler,Michele Paine McCullough,James D. Chappell,Mark R. Denison,Laura J. Stevens,Andrea J. Pruijssers,Adrian B. McDermott,Britta Flach,Nicole A. Doria-Rose,Kizzmekia S. Corbett,Kaitlyn M. Morabito,Sijy O’Dell,Stephen D. Schmidt,Phillip A. Swanson,Marcelino Padilla,John R. Mascola,Kathleen M. Neuzil,Hamilton Bennett,Wellington Sun,Etza Peters,Mat Makowski,Jim Albert,Kaitlyn Cross,Wendy Buchanan,Rhonda Pikaart-Tautges,Julie E. Ledgerwood,Barney S. Graham,John H. Beigel +32 more
TL;DR: The mRNA-1273 vaccine induced anti-SARS-CoV-2 immune responses in all participants, and no trial-limiting safety concerns were identified, which support further development of this vaccine.
Journal ArticleDOI
Safety and Immunogenicity of SARS-CoV-2 mRNA-1273 Vaccine in Older Adults.
Evan J. Anderson,Nadine Rouphael,Alicia T. Widge,Lisa A. Jackson,Paul C. Roberts,Mamodikoe Makhene,James D. Chappell,Mark R. Denison,Laura J. Stevens,Andrea J. Pruijssers,Adrian B. McDermott,Britta Flach,Bob C. Lin,Nicole A. Doria-Rose,Sijy O'Dell,Stephen D. Schmidt,Kizzmekia S. Corbett,Phillip A. Swanson,Marcelino Padilla,Kathy M. Neuzil,Hamilton Bennett,Brett A. Leav,Mat Makowski,Jim Albert,Kaitlyn Cross,Venkata Viswanadh Edara,Katharine Floyd,Mehul S. Suthar,David R. Martinez,Ralph S. Baric,Wendy Buchanan,Catherine J. Luke,Varun K Phadke,Christina A. Rostad,Julie E. Ledgerwood,Barney S. Graham,John H. Beigel +36 more
TL;DR: The phase 1, dose-escalation, open-label trial of a messenger RNA vaccine, mRNA-1273, which encodes the stabilized prefusion SARS-CoV-2 spike protein in healthy adults found it induced higher binding- and neutralizing-antibody titers than the 25-μg dose, which supports the use of the 100- μg dose in a phase 3 vaccine trial.
Journal ArticleDOI
Symbiotic lactobacilli stimulate gut epithelial proliferation via Nox‐mediated generation of reactive oxygen species
Rheinallt M. Jones,Liping Luo,Courtney S. Ardita,Arena N Richardson,Young Man Kwon,Jeffrey W. Mercante,Ashfaqul Alam,Cymone Gates,Huixia Wu,Phillip A. Swanson,J. David Lambeth,Patricia W. Denning,Andrew S. Neish +12 more
TL;DR: It is reported that commensal bacteria, particularly members of the genus Lactobacillus, can stimulate NADPH oxidase 1 (Nox1)‐dependent ROS generation and consequent cellular proliferation in intestinal stem cells upon initial ingestion into the murine or Drosophila intestine.
Journal ArticleDOI
Prevention of tuberculosis in macaques after intravenous BCG immunization
Patricia A. Darrah,Joseph J. Zeppa,Pauline Maiello,Joshua A Hackney,Marc H. Wadsworth,Marc H. Wadsworth,Marc H. Wadsworth,Travis K. Hughes,Travis K. Hughes,Travis K. Hughes,Supriya Pokkali,Phillip A. Swanson,Nicole L. Grant,Mark Rodgers,Megha Kamath,Chelsea M Causgrove,Dominick Laddy,Aurelio Bonavia,Danilo R. Casimiro,Philana Ling Lin,Edwin Klein,Alexander G. White,Charles A. Scanga,Alex K. Shalek,Mario Roederer,JoAnne L. Flynn,Robert A. Seder +26 more
TL;DR: The finding that intravenous BCG prevents or substantially limits Mtb infection in highly susceptible rhesus macaques has important implications for vaccine delivery and clinical development, and provides a model for defining immune correlates and mechanisms of vaccine-elicited protection against tuberculosis.
Journal ArticleDOI
Viral diseases of the central nervous system.
TL;DR: This review highlights a selection of neurotropic viruses that infect the CNS and explores the means by which they induce neurological diseases such as meningitis, encephalitis, and myelitis.