V
Varuna Aluvihare
Researcher at University of Cambridge
Publications - 58
Citations - 3093
Varuna Aluvihare is an academic researcher from University of Cambridge. The author has contributed to research in topics: Liver transplantation & Transplantation. The author has an hindex of 16, co-authored 42 publications receiving 2830 citations. Previous affiliations of Varuna Aluvihare include Wellcome Trust & King's College London.
Papers
More filters
Journal ArticleDOI
Regulatory T cells mediate maternal tolerance to the fetus.
TL;DR: An alloantigen-independent, systemic expansion of the maternal CD25+ T cell pool during pregnancy is demonstrated and it is shown that this population contains dominant regulatory T cell activity.
Journal ArticleDOI
B cells and professional APCs recruit regulatory T cells via CCL4.
TL;DR: Using gene expression profiling, it is shown that activation of B cells and professional antigen-presenting cells (APCs) induces the expression of common chemokines, and CCL4 was the most potent chemoattractant of a CD4+CD25+ T cell population, which is a characteristic phenotype of regulatory T cells.
Journal ArticleDOI
Nef triggers a transcriptional program in T cells imitating single-signal T cell activation and inducing HIV virulence mediators.
TL;DR: Nef acts as a master switch early in the viral life cycle, forcing an environment conducive to dynamic viral production and upregulates factors positively regulating HIV, including Tat-SF1, U1 SNRNP, and IRF-2.
Journal ArticleDOI
Liver transplantation in patients over 60 and 65 years: an evaluation of long-term outcomes and survival.
Timothy J.S. Cross,Charalambos G. Antoniades,Paolo Muiesan,Thawab Al-Chalabi,Varuna Aluvihare,Kosh Agarwal,Bernard Portmann,Mohammed Rela,Nigel Heaton,John O'Grady,Michael A. Heneghan +10 more
TL;DR: It is suggested that survival of patients over 60 and 65 yr undergoing LT is satisfactory, at least in the first 5‐yr posttransplantation, and patients over 65 yr experience less rejection, with good graft survival.
Journal ArticleDOI
Tolerance, suppression and the fetal allograft
TL;DR: The mechanisms that mediate materno-fetal tolerance are reviewed, with particular emphasis on changes in regulatory T cell function during pregnancy, and their implications are discussed.