V
Venugopal Gudipati
Researcher at Medical University of Vienna
Publications - 17
Citations - 667
Venugopal Gudipati is an academic researcher from Medical University of Vienna. The author has contributed to research in topics: Cytotoxic T cell & Immunology. The author has an hindex of 7, co-authored 12 publications receiving 463 citations. Previous affiliations of Venugopal Gudipati include Graz University of Technology & University of Glasgow.
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Journal ArticleDOI
The human flavoproteome.
TL;DR: Graphical abstract Highlights ► 89 genes encoding flavoproteins were identified in the human genome, and flavoenzymes play a critical role in folate and cobalamin metabolism.
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E3 ubiquitin ligases and plant innate immunity
TL;DR: The role of E3 ubiquitin ligases in mediating plant defence signalling is reviewed and examples where pathogens impinge on the host's ubiquitination machinery acting as molecular mimics to undermine defence are also highlighted.
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SARS-CoV-2 mutations in MHC-I-restricted epitopes evade CD8 + T cell responses.
Benedikt Agerer,Maximilian Koblischke,Venugopal Gudipati,Luis F Montano-Gutierrez,Mark J. Smyth,Alexandra Popa,Jakob-Wendelin Genger,Lukas Endler,David M. Florian,Vanessa Mühlgrabner,Marianne Graninger,Stephan W. Aberle,Anna-Maria Husa,Lisa Ellen Shaw,Alexander Lercher,Pia Gattinger,Ricard Torralba-Gombau,Doris Trapin,Thomas Penz,Daniele Barreca,Ingrid Fae,S. Wenda,Marianna Traugott,Gernot Walder,Winfried F. Pickl,Winfried F. Pickl,Volker Thiel,Franz Allerberger,Hannes Stockinger,Elisabeth Puchhammer-Stöckl,Wolfgang Weninger,Gottfried Fischer,Wolfgang Hoepler,Erich Pawelka,Alexander Zoufaly,Rudolf Valenta,Christoph Bock,Christoph Bock,Wolfgang Paster,René Geyeregger,Matthias Farlik,Florian Halbritter,Johannes B. Huppa,Judith H. Aberle,Andreas Bergthaler +44 more
TL;DR: In this paper, nonsynonymous mutations in MHC-I-restricted CD8+ T cell epitopes were identified after deep sequencing of 747 SARS-CoV-2 virus isolates.
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Inefficient CAR-proximal signaling blunts antigen sensitivity
Venugopal Gudipati,Julian Rydzek,Iago Doel-Perez,Vasco Dos Reis Gonçalves,Lydia Scharf,Lydia Scharf,Sebastian Königsberger,Sebastian Königsberger,Elisabeth Lobner,Renate Kunert,Hermann Einsele,Hannes Stockinger,Michael Hudecek,Johannes B. Huppa +13 more
TL;DR: While CARs outperformed T cell antigen receptors with regard to antigen binding within the immunological synapse, proximal signaling was significantly attenuated due to inefficient recruitment of the tyrosine-protein kinase ZAP-70 to ligated CARs and its reduced concomitant activation and subsequent release.
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Collapse of the native structure caused by a single amino acid exchange in human NAD(P)H:quinone oxidoreductase1
Wolf-Dieter Lienhart,Venugopal Gudipati,Michael K. Uhl,Alexandra Binter,Sergio Pulido,Robert Saf,Klaus Zangger,Karl Gruber,Peter Macheroux +8 more
TL;DR: The crystal structure of NQO1 P187S is solved and it is demonstrated that the single amino acid exchange destabilized interactions between the core and C‐terminus, leading to depopulation of the native structure in solution, severely compromising the catalytic capacity of the variant protein.