V
Vera Fantl
Researcher at Lincoln's Inn
Publications - 20
Citations - 1548
Vera Fantl is an academic researcher from Lincoln's Inn. The author has contributed to research in topics: Cancer & Antigen. The author has an hindex of 15, co-authored 20 publications receiving 1521 citations.
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Journal Article
Amplification and Overexpression of Cyclin D1 in Breast Cancer Detected by Immunohistochemical Staining
Cheryl Gillett,Vera Fantl,Rosalind Smith,C. J. Fisher,Jiri Bartek,Clive Dickson,Diana M Barnes,Gordon Peters +7 more
TL;DR: The results suggest that the frequency of overexpression is much higher than previously concluded from DNA-based analyses and that more than one-third of human breast cancers may contain excessive levels of cyclin D1.
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Amplification of chromosome band 11q13 and a role for cyclin D1 in human breast cancer.
Clive Dickson,Vera Fantl,Cheryl Gillett,Sharon Brookes,J. Bartek,Rosalind Smith,C. J. Fisher,Diana M. Barnes,Gordon Peters +8 more
TL;DR: Investigation on the mouse mammary tumor virus model of breast cancer resulted in the identification of an amplified region of DNA on human chromosome 11 band q13, indicating that cyclin D1 is expressed at elevated levels in around 40% of breast cancers, including those with the 11q13 amplification.
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Gene amplification on chromosome band 11q13 and oestrogen receptor status in breast cancer.
Vera Fantl,Michael Richards,Rosalind Smith,Lammie Ga,G. Johnstone,D. Allen,Walter M Gregory,Gordon Peters,Clive Dickson,Diana M. Barnes +9 more
TL;DR: Analysis of DNA from 183 primary breast cancers for amplification or rearrangement of a number of cellular proto-oncogenes confirms that the q13 region of chromosome 11, in which INT2 and HST1 are tandemly linked, is modestly amplified in approximately 15% of primary human breast cancers.
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Tyrosine kinase signalling in breast cancer: Fibroblast growth factors and their receptors
TL;DR: In some mammary tumours of MMTV-infected mouse strains, integration of viral genomic DNA into the somatic DNA of mammary epithelial cells was found to have caused the inappropriate expression of members of this family of growth factors.
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Impaired Mammary Gland Development in Cyl-1−/− Mice during Pregnancy and Lactation Is Epithelial Cell Autonomous
TL;DR: The biochemical analysis suggests that there is a cumulative delay in growth and differentiation of the mammary gland during pregnancy that results in a severely compromised gland when, at parturition, further development is curtailed by the abrupt change in hormonal milieu.