Verónica Corrales-Sánchez

TL;DR: Activation of the PI3K/AKT/mTOR pathway, especially if measured by loss of PTEN expression or increased expression/activation of downstream components is associated with poor survival, and PIK3CA mutational status is not associated with adverse outcome.

TL;DR: The data suggest that UBE2T and DTL may have a role in the pathophysiology of breast and lung tumors, opening avenues for future clinical evaluation of agents targeting those proteins or their pathways.

TL;DR: A synthetic lethality interaction between CHEK1 and AURKA inhibitors with potential translation to the clinical setting is identified by using an in silico approach and is linked with detrimental outcome in patients.

TL;DR: High levels of total cfDNA and presence of ctDNA are associated with worse survival in solid tumors, and Circulating DNA is associated with better outcome inSolid tumors.

TL;DR: Targeted drugs with companion diagnostics are associated with improved safety, and tolerability, and compared to control groups, targeted drugs in experimental arms were associated with increased odds of treatment discontinuation, grade 3/4 AEs, and toxic death irrespective of whether they utilized companiondiagnostics.