Vicente Valenzuela

TL;DR: Trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5, and trehalose administration enhanced the nuclear translocation of FOXO1, an important transcription factor involved in the activation of autophagic in neurons.

TL;DR: A functional role of the UPR is demonstrated in SCI, offering novel therapeutic targets to treat this invalidating condition and demonstrating a fast ER stress reaction involving the upregulation of key components of the unfolded protein response (UPR).

TL;DR: Most recent advances attributing a causal role of ER stress in ALS are reviewed and quantitative changes in ER stress-responsive chaperones in body fluids have been proposed as possible biomarkers to monitor the disease progression.

TL;DR: A novel and simple strategy to express an autophagy flux reporter in the nervous system of adult animals by the intraventricular delivery of adeno-associated viruses into newborn mice is described.

TL;DR: The data support a dual role of BECN1 in ALS and depict a complex scenario in terms of predicting the effects of manipulating autophagy in a disease context.