B
Brigitte van Zundert
Researcher at Andrés Bello National University
Publications - 58
Citations - 2832
Brigitte van Zundert is an academic researcher from Andrés Bello National University. The author has contributed to research in topics: Hippocampal formation & Epigenetics. The author has an hindex of 27, co-authored 53 publications receiving 2312 citations. Previous affiliations of Brigitte van Zundert include Pontifical Catholic University of Chile & Harvard University.
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Journal ArticleDOI
Trehalose delays the progression of amyotrophic lateral sclerosis by enhancing autophagy in motoneurons.
Karen Castillo,Melissa Nassif,Vicente Valenzuela,Fabiola Rojas,Soledad Matus,Gabriela Mercado,Felipe A. Court,Brigitte van Zundert,Claudio Hetz,Claudio Hetz +9 more
TL;DR: Trehalose treatment led to a significant upregulation in the expression of key autophagy-related genes at the mRNA level including Lc3, Becn1, Sqstm1 and Atg5, and trehalose administration enhanced the nuclear translocation of FOXO1, an important transcription factor involved in the activation of autophagic in neurons.
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Receptor compartmentalization and trafficking at glutamate synapses: a developmental proposal.
TL;DR: A model of glutamatergic synaptic differentiation is proposed, in which different NMDA receptor scaffolding and signaling complexes effect the trafficking and synaptic localization of NR2A-rich and NR2B-rich receptors, leading to tangential compartmentalization of these receptors and their movement between synaptic and extrasynaptic compartments.
Journal ArticleDOI
Neonatal Neuronal Circuitry Shows Hyperexcitable Disturbance in a Mouse Model of the Adult-Onset Neurodegenerative Disease Amyotrophic Lateral Sclerosis
Brigitte van Zundert,Marieke H. Peuscher,Meri Hynynen,Adam Chen,Rachael L. Neve,Robert H. Brown,Martha Constantine-Paton,Mark C. Bellingham,Mark C. Bellingham +8 more
TL;DR: These findings underscore the widespread and early onset of abnormal neural activity in this mouse model of the adult neurodegenerative disease ALS, and suggest that suppression of PCNa and hyperexcitability early in life might be one way to mitigate or prevent cell death in the adult CNS.
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Vitamin C is an essential antioxidant that enhances survival of oxidatively stressed human vascular endothelial cells in the presence of a vast molar excess of glutathione.
Viviana P. Montecinos,Paula Guzmán,Valeria Barra,Marcelo Villagrán,Carola Muñoz-Montesino,Kirsty Sotomayor,Elizabeth Escobar,Alejandro Godoy,Lorena Mardones,Paula Sotomayor,Catherine Guzmán,Osmán Vásquez,Victoria Gallardo,Brigitte van Zundert,María Rosa Bono,Sergio A. Onate,Marcelo E. Bustamante,Juan G. Cárcamo,Coralia I. Rivas,Juan Carlos Vera +19 more
TL;DR: In endothelial cells under oxidative challenge, vitamin C functions as an essential cellular antioxidant even in the presence of a vast molar excess of glutathione.
Journal ArticleDOI
Epigenetic editing of the Dlg4/PSD95 gene improves cognition in aged and Alzheimer's disease mice
Fernando J. Bustos,Estibaliz Ampuero,Nur Jury,Rodrigo Aguilar,Fahimeh Falahi,Jorge Toledo,Juan Ahumada,Jaclyn Lata,Paula Cubillos,Berta Henriquez,Miguel V. Guerra,Jimmy Stehberg,Rachael L. Neve,Nibaldo C. Inestrosa,Ursula Wyneken,Marco Fuenzalida,Steffen Härtel,Miguel Sena-Esteves,Lorena Varela-Nallar,Marianne G. Rots,Martin Montecino,Brigitte van Zundert +21 more
TL;DR: This work validates PSD95 as a key player in memory and establishes epigenetic editing as a potential therapy to treat human neurological disorders.