V
Vicki L. McDonald
Researcher at Bristol-Myers Squibb
Publications - 11
Citations - 2251
Vicki L. McDonald is an academic researcher from Bristol-Myers Squibb. The author has contributed to research in topics: Amphiregulin & Epidermal growth factor. The author has an hindex of 9, co-authored 11 publications receiving 2206 citations.
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Journal ArticleDOI
Structure and function of human amphiregulin: a member of the epidermal growth factor family
TL;DR: The complete amino acid sequence of amphiregulin, a bifunctional cell growth modulator, was determined and it was found that it fully supplants the requirement for EGF or transforming growth factor-alpha in murine keratinocyte growth, but it is a much weaker growth stimulator in other cell systems.
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Molecular cloning and expression of an additional epidermal growth factor receptor-related gene.
Gregory D. Plowman,Gena S. Whitney,Michael G. Neubauer,Janell M. Green,Vicki L. McDonald,George J. Todaro,Mohammed Shoyab +6 more
TL;DR: The cloning of another member of the human EGF receptor (HER) family of receptor tyrosine kinases, which is named "HER3/ERRB3" is reported and generated peptide-specific antisera that recognizes the 160-kDa HER3 protein when transiently expressed in COS cells.
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The amphiregulin gene encodes a novel epidermal growth factor-related protein with tumor-inhibitory activity.
Gregory D. Plowman,Janell M. Green,Vicki L. McDonald,Michael G. Neubauer,Christine M. Disteche,George J. Todaro,Mohammed Shoyab +6 more
TL;DR: Human placenta and ovaries were found to express significant amounts of the 1.4-kilobase AR transcript, implicating AR in the regulation of normal cell growth, and the gene was localized to chromosomal region 4q13-4q21, a common breakpoint for acute lymphoblastic leukemia.
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Amphiregulin: a bifunctional growth-modulating glycoprotein produced by the phorbol 12-myristate 13-acetate-treated human breast adenocarcinoma cell line MCF-7.
TL;DR: The amino-terminal amino acid sequence of AR has been determined, and no significant sequence homology between AR and other proteins was found, and the molecule thus appears to be a distinct growth regulatory protein.
Journal ArticleDOI
The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth.
Gregory D. Plowman,Janell M. Green,Michael G. Neubauer,Sharon D. Buckley,Vicki L. McDonald,G.J. Todaro,Mohammed Shoyab +6 more
TL;DR: The broad expression profile of epithelin transcripts, along with the opposing activities of the two mature protein products, implicates these factors as natural mediators of epithelial homeostasis.