Dynamics of Phononic Materials and Structures: Historical Origins, Recent Progress, and Future Outlook

The clinical viability of a method of acoustic remote palpation, capable of imaging local variations in the mechanical properties of soft tissue using acoustic radiation force impulse (ARFI) imaging, is investigated in vivo. In this method, focused ultrasound (US) is used to apply localized radiation force to small volumes of tissue (2 mm(3)) for short durations (less than 1 ms) and the resulting tissue displacements are mapped using ultrasonic correlation-based methods. The tissue displacements are inversely proportional to the stiffness of the tissue and, thus, a stiffer region of tissue exhibits smaller displacements than a more compliant region. Due to the short duration of the force application, this method provides information about the mechanical impulse response of the tissue, which reflects variations in tissue viscoelastic characteristics. In this paper, experimental results are presented demonstrating that displacements on the order of 10 microm can be generated and detected in soft tissues in vivo using a single transducer on a modified diagnostic US scanner. Differences in the magnitude of displacement and the transient response of tissue are correlated with tissue structures in matched B-mode images. The results comprise the first in vivo ARFI images, and support the clinical feasibility of a radiation force-based remote palpation imaging system.

Acoustic radiation force impulse imaging: in vivo demonstration of clinical feasibility.

This article reviews acoustic microfiuidics: the use of acoustic fields, principally ultrasonics, for application in microfiuidics. Although acoustics is a classical field, its promising, and indeed perplexing, capabilities in powerfully manipulating both fluids and particles within those fluids on the microscale to nanoscale has revived interest in it. The bewildering state of the literature and ample jargon from decades of research is reorganized and presented in the context of models derived from first principles. This hopefully will make the area accessible for researchers with experience in materials science, fluid mechanics, or dynamics. The abundance of interesting phenomena arising from nonlinear interactions in ultrasound that easily appear at these small scales is considered, especially in surface acoustic wave devices that are simple to fabricate with planar lithography techniques common in microfluidics, along with the many applications in microfluidics and nanofluidics that appear through the literature.

/pdf/microscale-acoustofluidics-microfluidics-driven-via-5bet39j13p.pdf

Microscale acoustofluidics: Microfluidics driven via acoustics and ultrasonics

A method of acoustic remote palpation, capable of imaging local variations in the mechanical properties of tissue, is under investigation. In this method, focused ultrasound is used to apply localized (on the order of 2 mm3) radiation force within tissue. and the resulting tissue displacements are mapped using ultrasonic correlation based methods. The tissue displacements are inversely proportional to the stiffness of the tissue, and thus a stiffer region of tissue exhibits smaller displacements than a more compliant region. In this paper, the feasibility of remote palpation is demonstrated experimentally using breast tissue phantoms with spherical lesion inclusions, and in vitro liver samples. A single diagnostic transducer and modified ultrasonic imaging system are used to perform remote palpation. The displacement images are directly correlated to local variations in tissue stiffness with higher contrast than the corresponding B-mode images. Relationships between acoustic beam parameters, lesion characteristics and radiation force induced tissue displacement patterns are investigated and discussed. The results show promise for the clinical implementation of remote palpation.

On the feasibility of remote palpation using acoustic radiation force.

The nondestructive assessment of the damage that occurs in components during service plays a key role for condition monitoring and residual life estimation of in-service components/structures. Ultrasound has been widely utilized for this; however most of these conventional methods using ultrasonic characteristics in the linear elastic region are only sensitive to gross defects but much less sensitive to micro-damage. Recently, the nonlinear ultrasonic technique, which uses nonlinear ultrasonic behavior such as higher-harmonic generation, subharmonic generation, nonlinear resonance, or mixed frequency response, has been studied as a positive method for overcoming this limitation. In this paper, overall progress in this technique is reviewed with the brief introduction of basic principle in the application of each nonlinear ultrasonic phenomenon.

Nonlinear ultrasonic techniques for nondestructive assessment of micro damage in material: A review

The basic physical characteristics of ultrasound waves are reviewed in terms of the typical displacements, velocities, accelerations and pressures generated in various fluid media as a function of frequency. The effects on wave propagation of interfaces are considered, and the way in which waves are reflected, transmitted and mode converted at interfaces introduced. Then the nonlinear propagation of high amplitude ultrasound is explained, and its consequences, including the generation of harmonic frequencies and enhanced attenuation, considered. The absorption of ultrasonic waves and the resulting heat deposition in absorbing media are described together with factors determining the resulting temperature rises obtained. In the case of tissue these include conduction and perfusion. The characteristics of cavitation in fluid media are also briefly covered. Finally, secondary nonlinear physical effects are described. These include radiation forces on interfaces and streaming in fluids.

Ultrasound and matter--physical interactions.

Nonlinear propagation in ultrasonic fields: measurements, modelling and harmonic imaging

Streaming is shown to occur in water in the focused beams produced by a number of medical pulseecho devices. The use of hot film anemometry to measure the streaming velocity is described and velocities measured in water using commercial equipment are quoted. The highest velocities occur in pulsed Doppler mode with a maximum velocity of 14 cm s −1 being observed. An experimental set-up was used to investigate the parameters affecting streaming and it was found that the harmonic content of the pulse waveform had a major effect on the streaming velocity. The time taken for a stream to become established at the focus of the acoustic beams studied was typically approximately 0.5 s.

An experimental investigation of streaming in pulsed diagnostic ultrasound beams

This paper considers some non-thermal effects resulting from absorption of acoustic energy from an ultrasound beam. An experimental investigation of the location of the 'source pump', responsible for the generation of streaming in high amplitude diagnostic fields in water, is reported. Acoustically transparent membranes were inserted in the ultrasound field in order to restrict the streaming volume. It is shown that the major contribution to an acoustic stream is generated in the region near to the focus of a transducer where the intensity in the beam and the degree of non-linear distortion are both high. In the second part of the paper a simple model of non-linear propagation is used to predict the magnitude of the maximum pressure gradient induced in a medium by the absorption of acoustic energy from a beam. Propagation in water, in tissue and in amniotic fluid are considered. Within the limitations of this model it is shown that the pressure gradients induced in pulsed acoustic fields do not result in the ultimate shear stress of tissue being exceeded.

Forces acting in the direction of propagation in pulsed ultrasound fields

The progressive development of finite-amplitude distortion of ultrasonic pulses has been investigated in excised bovine liver using pulsed focused ultrasonic beams at nominal frequencies of 2.5 and 3.5 MHz. Both the transducers and the powers used were those which may be encountered with clinical imaging equipment. Significant distortion of the waveform was observed to occur, particularly at higher powers. For example, at 2.5 MHz, with a mean input pressure (p0) of 0.58 MPa, the second harmonic in the pulse spectrum showed a maximum value 10.5 dB below the fundamental and the highest third harmonic component was 19 dB below the fundamental. These particular observations illustrate that finite-amplitude distortion may be of considerable significance in the transmission through tissue of ultrasonic pulses during diagnostic scanning.

http://iopscience.iop.org/article/10.1088/0031-9155/31/12/007/pdf

Victor F. Humphrey

Papers

Ultrasound and matter--physical interactions.

Nonlinear propagation in ultrasonic fields: measurements, modelling and harmonic imaging

An experimental investigation of streaming in pulsed diagnostic ultrasound beams

Forces acting in the direction of propagation in pulsed ultrasound fields

The development of harmonic distortion in pulsed finite-amplitude ultrasound passing through liver.