V
Victoria Balannik
Researcher at Northwestern University
Publications - 10
Citations - 964
Victoria Balannik is an academic researcher from Northwestern University. The author has contributed to research in topics: M2 proton channel & Influenza A virus. The author has an hindex of 10, co-authored 10 publications receiving 906 citations. Previous affiliations of Victoria Balannik include University of Pennsylvania & Howard Hughes Medical Institute.
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Journal ArticleDOI
Structure and mechanism of proton transport through the transmembrane tetrameric M2 protein bundle of the influenza A virus.
Rudresh Acharya,Vincenzo Carnevale,Giacomo Fiorin,Benjamin G. Levine,Alexei L. Polishchuk,Victoria Balannik,Ilan Samish,Robert A. Lamb,Lawrence H. Pinto,William F. DeGrado,Michael L. Klein +10 more
TL;DR: The conformation of the transmembrane protein, which is intermediate between structures previously solved at higher and lower pH, suggests a mechanism by which conformational changes might facilitate asymmetric diffusion through the channel in the presence of a proton gradient.
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Influenza Virus M2 Ion Channel Protein Is Necessary for Filamentous Virion Formation
Jeremy S. Rossman,Xianghong Jing,Xianghong Jing,George P. Leser,Victoria Balannik,Lawrence H. Pinto,Robert A. Lamb +6 more
TL;DR: It is found that an amphipathic helix located within the M2 cytoplasmic tail is able to bind cholesterol, and it is speculated that M2 cholesterol binding is essential for both filament formation and the stability of existing viral filaments.
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Design and pharmacological characterization of inhibitors of amantadine-resistant mutants of the M2 ion channel of influenza A virus
Victoria Balannik,Jun Wang,Yuki Ohigashi,Xianghong Jing,Emma Magavern,Robert A. Lamb,William F. DeGrado,Lawrence H. Pinto +7 more
TL;DR: These findings help to define the location and mechanism of binding of M2 channel-blocking drugs but also demonstrate the feasibility of discovering new inhibitors that target this binding site in a number of amantadine-resistant mutants.
Journal ArticleDOI
Functional studies and modeling of pore-lining residue mutants of the influenza a virus M2 ion channel.
Victoria Balannik,Vincenzo Carnevale,Giacomo Fiorin,Benjamin G. Levine,Robert A. Lamb,Michael L. Klein,William F. DeGrado,Lawrence H. Pinto +7 more
TL;DR: The set of functionally fit mutants of A/M2 that should be targeted when considering the design of novel drugs that inhibit amantadine-resistant strains of influenza A virus is defined.
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Discovery of Spiro-Piperidine Inhibitors and Their Modulation of the Dynamics of the M2 Proton Channel from Influenza A Virus
TL;DR: Structural-activity relation data suggest that spiro-piperidine 9 binds more extensively with the AM2 channel, thus leading to stronger inhibitory potency.