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Yelena Ginzburg
Researcher at New York Blood Center
Publications - 58
Citations - 2423
Yelena Ginzburg is an academic researcher from New York Blood Center. The author has contributed to research in topics: Erythropoiesis & Hepcidin. The author has an hindex of 18, co-authored 40 publications receiving 2113 citations. Previous affiliations of Yelena Ginzburg include Albert Einstein College of Medicine.
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Journal ArticleDOI
Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non–transferrin-bound iron
Eldad A. Hod,Gary M. Brittenham,Genia B. Billote,Richard O. Francis,Yelena Ginzburg,Jeanne E. Hendrickson,Jeffrey S. Jhang,Joseph E. Schwartz,Shruti Sharma,Sujit Sheth,Anthony N. Sireci,Hannah L. Stephens,Brie A. Stotler,Boguslaw S. Wojczyk,James C. Zimring,Steven L. Spitalnik +15 more
TL;DR: In this article, the authors compared fresh and older RBCs and found that the older transfusion increased transferrin saturation progressively over 4 hours to a mean of 64% and non-transferrin-bound iron appeared.
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An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Michael Dussiot,Thiago Trovati Maciel,Aurélie Fricot,Céline Chartier,Olivier Negre,Joel Veiga,Damien Grapton,Etienne Paubelle,Emmanuel Payen,Yves Beuzard,Philippe Leboulch,Jean-Antoine Ribeil,Jean-Benoît Arlet,Francine Côté,Geneviève Courtois,Yelena Ginzburg,Thomas O. Daniel,Rajesh Chopra,Victoria Sung,Olivier Hermine,Ivan C. Moura +20 more
TL;DR: Observations suggest that ActRIIA ligand traps may have therapeutic relevance in β-thalassemia by suppressing the deleterious effects of GDF11, a cytokine which blocks terminal erythroid maturation through an autocrine amplification loop involving oxidative stress and α-globin precipitation.
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Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
Sara Gardenghi,Pedro Ramos,Pedro Ramos,Maria F. Marongiu,Luca Melchiori,Laura Breda,Ella Guy,Kristen Muirhead,Niva Rao,Cindy N. Roy,Nancy C. Andrews,Elizabeta Nemeth,Antonia Follenzi,Xiuli An,Narla Mohandas,Yelena Ginzburg,Eliezer A. Rachmilewitz,Patricia J. Giardina,Robert W. Grady,Stefano Rivella +19 more
TL;DR: It is demonstrated that a moderate increase in expression of hepcidin in β-thalassemic mice limits iron overload, decreases formation of insoluble membrane-bound globins and reactive oxygen species, and improves anemia.
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Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice
Emilio Ramos,Léon Kautz,Richard Rodriguez,Michael Hansen,Victoria Gabayan,Yelena Ginzburg,Marie-Paule Roth,Elizabeta Nemeth,Tomas Ganz +8 more
TL;DR: A model in which acute increases in holotransferrin concentrations transmitted through HFE, TfR2, and HJV augment BMP receptor sensitivity to BMPs is supported and a distinct regulatory mechanism that senses hepatic iron may modulate hepcidin response to chronic iron loading is proposed.
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Transferrin therapy ameliorates disease in beta-thalassemic mice.
Huihui Li,Anne C Rybicki,Sandra M. Suzuka,Leni von Bonsdorff,William Breuer,Charles B. Hall,Z. Ioav Cabantchik,Eric E. Bouhassira,Mary E. Fabry,Yelena Ginzburg +9 more
TL;DR: It is suggested that transferrin therapy might be beneficial in human β-thalassemia and reduce reticulocytosis, erythropoietin abundance and splenomegaly by increasing the amount of circulating transferrin.