V
Vigdis T. Gautvik
Researcher at University of Oslo
Publications - 30
Citations - 4383
Vigdis T. Gautvik is an academic researcher from University of Oslo. The author has contributed to research in topics: Parathyroid hormone & Osteoporosis. The author has an hindex of 16, co-authored 28 publications receiving 4064 citations. Previous affiliations of Vigdis T. Gautvik include Oslo University Hospital.
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Journal ArticleDOI
The hypocretins: Hypothalamus-specific peptides with neuroexcitatory activity
L de Lecea,Thomas S. Kilduff,Christelle Peyron,Xiao-Bing Gao,Pamela E. Foye,Patria E. Danielson,C. Fukuhara,Elena Battenberg,Vigdis T. Gautvik,Frederick S. Bartlett,Wayne N. Frankel,A. N. van den Pol,Floyd E. Bloom,Kaare M. Gautvik,J G Sutcliffe +14 more
TL;DR: A hypothalamus-specific mRNA is described that encodes preprohypocretin, the putative precursor of a pair of peptides that share substantial amino acid identities with the gut hormone secretin, suggesting that the hypocretins function within the CNS as neurotransmitters.
Journal ArticleDOI
Eight genes are highly associated with BMD variation in postmenopausal Caucasian women
Sjur Reppe,Hilde Refvem,Vigdis T. Gautvik,Ole Kristoffer Olstad,Per I. Høvring,Finn P. Reinholt,Marit Holden,Arnoldo Frigessi,Arnoldo Frigessi,Rune Jemtland,Kaare M. Gautvik +10 more
TL;DR: The transcriptional changes in 84 trans-iliacal bone biopsies associated with BMD variations in postmenopausal females, aiming to identify genetic determinants of bone structure, provide novel insight in the underlying biology of bone metabolism and osteoporosis which is the ultimate consequence of low BMD.
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Methylation of Bone SOST , its mRNA, and Serum Sclerostin Levels Correlate Strongly With Fracture Risk in Postmenopausal Women
Sjur Reppe,Agate Noer,Runa M. Grimholt,Bjarni V. Halldorsson,Carolina Medina-Gomez,Vigdis T. Gautvik,Ole Kristoffer Olstad,Jens P. Berg,Harish K. Datta,Karol Estrada,Albert Hofman,André G. Uitterlinden,Fernando Rivadeneira,Robert Lyle,Philippe Collas,Kaare M. Gautvik +15 more
TL;DR: The observations suggest that increased SOST promoter methylation seen in OP is a compensatory counteracting mechanism, which lowers serum sclerostin concentrations and reduces inhibition of Wnt signaling in an attempt to promote bone formation.
Journal ArticleDOI
Osteopenia, decreased bone formation and impaired osteoblast development in Sox4 heterozygous mice.
Lise Sofie H. Nissen-Meyer,Rune Jemtland,Vigdis T. Gautvik,Mona Elisabeth Pedersen,Rita Paro,Dario Fortunati,Dominique D. Pierroz,Vincent A. Stadelmann,Sjur Reppe,Finn P. Reinholt,Andrea Del Fattore,Nadia Rucci,Anna Teti,Serge Ferrari,Kaare M. Gautvik +14 more
TL;DR: The results implicate the transcription factor Sox4 in regulation of bone formation, by acting upstream of Osx and independent of Runx2, and demonstrate inhibited formation and altered microarchitecture of bone in Sox4+/– mice versus WT, without apparent defects in bone resorption.
Journal ArticleDOI
Molecular disease map of bone characterizing the postmenopausal osteoporosis phenotype
Rune Jemtland,Marit Holden,Sjur Reppe,Ole Kristoffer Olstad,Finn P. Reinholt,Vigdis T. Gautvik,Hilde Refvem,Arnoldo Frigessi,Arnoldo Frigessi,Brian Houston,Kaare M. Gautvik,Kaare M. Gautvik +11 more
TL;DR: The results identify potential osteoporosis susceptibility candidate genes adjusted for confounding factors (ie, age and BMI) with or without a significant correlation with BMD.