V
Viktor Y. Butnev
Researcher at Wichita State University
Publications - 17
Citations - 478
Viktor Y. Butnev is an academic researcher from Wichita State University. The author has contributed to research in topics: Glycosylation & Follicle-stimulating hormone receptor. The author has an hindex of 10, co-authored 16 publications receiving 438 citations.
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Journal ArticleDOI
Structural features of mammalian gonadotropins
TL;DR: The biological activities exhibited by hybrid hormones, eLH alpha found to be greater than those of oLH and pLH provided an interesting exception to the general rule that the beta-subunit determines the potency of the heterodimer.
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Hypo-glycosylated human follicle-stimulating hormone (hFSH(21/18)) is much more active in vitro than fully-glycosylated hFSH (hFSH(24)).
George R. Bousfield,Vladimir Y. Butnev,Viktor Y. Butnev,Yasuaki Hiromasa,David Harvey,Jeffrey V. May +5 more
TL;DR: Hypo-glycosylated hFSH(21/18) was isolated from hLH preparations by immunoaffinity chromatography followed by gel filtration and bound rat FSHRs more rapidly, suggesting that more ligand binding sites are available to hFSI in FSHR than to fSH(24).
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Hypoglycosylated hFSH has greater bioactivity than fully glycosylated recombinant hFSH in human granulosa cells
Chao Jiang,Xiaoying Hou,Xiaoying Hou,Cheng Wang,Jeffrey V. May,Viktor Y. Butnev,George R. Bousfield,John S. Davis +7 more
TL;DR: Hypoglycosylated FSH may be useful in follicle stimulation protocols for older patients using assisted reproduction technologies, and has greater bioactivity than fully glycosylation of the FSHβ subunit, suggesting that age-dependent decreases in hypogly cosylated hFSH contribute to reduced ovarian responsiveness.
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Identification of Twelve O-Glycosylation Sites in Equine Chorionic Gonadotropin β and Equine Luteinizing Hormone β by Solid-Phase Edman Degradation
TL;DR: Comparison of the equid LH/CGβ sequences with those available for the primate CGβ subunits indicated a greater conservation of glycosylation patterns in the former.
Journal ArticleDOI
Carbohydrate analysis of glycoprotein hormones.
TL;DR: Complete carbohydrate composition analysis of glycoprotein hormones, their subunits, and oligosaccharides isolated from individual glycosylation sites can be accomplished using high-pH anion-exchange chromatography combined with pulsed amperometric detection.