V
Vincent Navarro
Researcher at Cornell University
Publications - 16
Citations - 2214
Vincent Navarro is an academic researcher from Cornell University. The author has contributed to research in topics: LNCaP & Monoclonal antibody. The author has an hindex of 11, co-authored 16 publications receiving 2078 citations. Previous affiliations of Vincent Navarro include NewYork–Presbyterian Hospital.
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Journal Article
Monoclonal Antibodies to the Extracellular Domain of Prostate-specific Membrane Antigen Also React with Tumor Vascular Endothelium
He Liu,Peggy Moy,Sae Kim,Yan Xia,Ayyappan K. Rajasekaran,Vincent Navarro,Beatrice S. Knudsen,Neil H. Bander +7 more
TL;DR: Competitive binding studies indicate these antibodies define two distinct, noncompeting epitopes on the extracellular domain of PSMA, which should prove useful for in vivo targeting to prostate cancer, as well as to the vascular compartment of a wide variety of carcinomas.
Journal Article
Constitutive and antibody-induced internalization of prostate-specific membrane antigen
He Liu,Ayyoppan K. Rajasekaran,Peggy Moy,Yan Xia,Sae Kim,Vincent Navarro,Rahmatullah Rahmati,Neil H. Bander +7 more
TL;DR: It is reported that viable LNCaP cells internalize four monoclonal antibodies that bind to the extracellular domain of PSMA, and it is suggested that PSMA might function as a receptor mediating the internalization of a putative ligand.
Journal ArticleDOI
Noninvasive measurement of androgen receptor signaling with a positron-emitting radiopharmaceutical that targets prostate-specific membrane antigen
Michael J. Evans,Peter Smith-Jones,John Wongvipat,Vincent Navarro,Sae Kim,Neil H. Bander,Steven M. Larson,Charles L. Sawyers +7 more
TL;DR: It is established that relative changes in PSMA expression levels can be quantitatively measured using a human-ready imaging reagent and could serve as a biomarker of AR signaling to noninvasively evaluate AR activity in patients with CRPC.
Journal Article
In Vitro Characterization of Radiolabeled Monoclonal Antibodies Specific for the Extracellular Domain of Prostate-specific Membrane Antigen
Peter Smith-Jones,Shankar Vallabahajosula,Stanley J. Goldsmith,Vincent Navarro,Catherine J. Hunter,Diego Bastidas,Neil H. Bander +6 more
TL;DR: In vitro characterization of three recently developed mAbs that bind the extracellular domain of PSMA (PSMAext) shows that J415 and J591 are promising mAbs for the targeting of viable PSMA-expressing tissue with diagnostic and therapeutic metallic radionuclides.
Journal ArticleDOI
Functional characterization of circulating tumor cells with a prostate-cancer-specific microfluidic device
Brian Kirby,Mona Jodari,Matthew S. Loftus,Gunjan Gakhar,Erica D. Pratt,Chantal Chanel-Vos,Jason P. Gleghorn,Steven M. Santana,He Liu,James P. Smith,Vincent Navarro,Scott T. Tagawa,Neil H. Bander,David M. Nanus,Paraskevi Giannakakou +14 more
TL;DR: A geometrically enhanced differential immunocapture (GEDI) microfluidic device that combines an anti-prostate specific membrane antigen (PSMA) antibody with a 3D geometry that captures CTCs while minimizing nonspecific leukocyte adhesion is developed.