J
John Wongvipat
Researcher at Memorial Sloan Kettering Cancer Center
Publications - 50
Citations - 12382
John Wongvipat is an academic researcher from Memorial Sloan Kettering Cancer Center. The author has contributed to research in topics: Prostate cancer & Androgen receptor. The author has an hindex of 30, co-authored 50 publications receiving 10575 citations. Previous affiliations of John Wongvipat include University of California, Los Angeles & University of California.
Papers
More filters
Journal ArticleDOI
Development of a Second-Generation Antiandrogen for Treatment of Advanced Prostate Cancer
Chris Tran,Samedy Ouk,Nicola J. Clegg,Yu Chen,Philip A. Watson,Vivek K. Arora,John Wongvipat,Peter Smith-Jones,Dongwon Yoo,Andrew Kwon,Teresa Wasielewska,Derek S. Welsbie,Charlie D. Chen,Celestia S. Higano,Tomasz M. Beer,David T. Hung,Howard I. Scher,Michael E. Jung,Charles L. Sawyers +18 more
TL;DR: The diarylthiohydantoins RD162 and MDV3100 are characterized, two compounds optimized from a screen for nonsteroidal antiandrogens that retain activity in the setting of increased androgen receptor expression that appear to be promising candidates for treatment of advanced prostate cancer.
Journal ArticleDOI
Organoid cultures derived from patients with advanced prostate cancer
Dong Gao,Ian Vela,Andrea Sboner,Phillip J. Iaquinta,Wouter R. Karthaus,Anuradha Gopalan,Catherine Dowling,Jackline Wanjala,Eva Undvall,Vivek K. Arora,John Wongvipat,Myriam Kossai,Sinan Ramazanoglu,Luendreo P Barboza,Wei Di,Zhen Cao,Qi Fan Zhang,Inna Sirota,Leili Ran,Theresa Y MacDonald,Himisha Beltran,Juan Miguel Mosquera,Karim Touijer,Peter T. Scardino,Vincent P. Laudone,Kristen Rebecca Curtis,Dana E. Rathkopf,Michael J. Morris,Michael J. Morris,Daniel C. Danila,Daniel C. Danila,Susan F. Slovin,Susan F. Slovin,Stephen B. Solomon,James A. Eastham,Ping Chi,Brett S. Carver,Mark A. Rubin,Howard I. Scher,Howard I. Scher,Hans Clevers,Charles L. Sawyers,Charles L. Sawyers,Yu Chen,Yu Chen +44 more
TL;DR: Using a 3D organoid system, this paper reported success in long-term culture of prostate cancer from biopsy specimens and circulating tumor cells, including TMPRSS2-ERG fusion, SPOP mutation, SPINK1 overexpression, and CHD1 loss.
Journal ArticleDOI
Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-Deficient Prostate Cancer
Brett S. Carver,Caren Chapinski,John Wongvipat,Haley Hieronymus,Yu Chen,Sarat Chandarlapaty,Vivek K. Arora,Carl Le,Jason A. Koutcher,Howard I. Scher,Peter T. Scardino,Neal Rosen,Charles L. Sawyers +12 more
TL;DR: Combined pharmacologic inhibition of PI3K and AR signaling caused near-complete prostate cancer regressions in a Pten-deficient murine prostate cancer model and in human prostate cancer xenografts, indicating that both pathways coordinately support survival.
Journal ArticleDOI
Glucocorticoid Receptor Confers Resistance to Antiandrogens by Bypassing Androgen Receptor Blockade
Vivek K. Arora,Emily Schenkein,Rajmohan Murali,Sumit K. Subudhi,John Wongvipat,Minna D. Balbas,Neel Shah,Ling Cai,Eleni Efstathiou,Chris Logothetis,Deyou Zheng,Charles L. Sawyers,Charles L. Sawyers +12 more
TL;DR: This work identifies induction of glucocorticoid receptor (GR) expression as a common feature of drug-resistant tumors in a credentialed preclinical model and establishes a mechanism of escape from AR blockade through expansion of cells primed to drive AR target genes via an alternative nuclear receptor upon drug exposure.
Journal ArticleDOI
Myc-driven murine prostate cancer shares molecular features with human prostate tumors.
Katharine Ellwood-Yen,Thomas G. Graeber,John Wongvipat,M. Luisa Iruela-Arispe,JianFeng Zhang,JianFeng Zhang,Robert J. Matusik,George Thomas,Charles L. Sawyers +8 more
TL;DR: To define Myc's functional role, transgenic mice expressing human c-Myc in the mouse prostate are generated and this approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.