V
Vincent W. Bowry
Researcher at The Heart Research Institute
Publications - 36
Citations - 5213
Vincent W. Bowry is an academic researcher from The Heart Research Institute. The author has contributed to research in topics: Radical & Low-density lipoprotein. The author has an hindex of 24, co-authored 36 publications receiving 5064 citations. Previous affiliations of Vincent W. Bowry include National Research Council & Australian National University.
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Journal ArticleDOI
Ubiquinol-10 protects human low density lipoprotein more efficiently against lipid peroxidation than does alpha-tocopherol
TL;DR: Investigation of the temporal disappearance of natural antioxidants associated with human low density lipoprotein (LDL) in relation to the appearance of various classes of lipid hydroperoxides shows that ubiquinol-10 is much more efficient in inhibiting LDL oxidation than either lycopene, beta-carotene, or alpha-tocopherol.
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Tocopherol-mediated peroxidation. The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein
Vincent W. Bowry,Roland Stocker +1 more
TL;DR: It is shown that α-TocH can be a strong prooxidant for the LDL itself, i.e., an aqueous dispersion of lipid-bearing particles in the form of alkylperoxyl radicals generated from a water-soluble azo initiator induced lipid peroxidation in LDL.
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Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant.
TL;DR: It is proposed that perodixation is propagated within lipoprotein particles by reaction of the vitamin E radical with polyunsaturated fatty acid moieties in the lipid, which explains how reagents which reduce the alpha-tocopheroxyl radical strongly inhibit lipid peroxidation in vitamin E-containing LDL.
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High density lipoprotein is the major carrier of lipid hydroperoxides in human blood plasma from fasting donors.
TL;DR: The data show that HDL is the principal vehicle for circulating plasma lipid hydroperoxides and suggest that HDL lipids may be more rapidly oxidized than those in LDL in vivo, and could imply a possible beneficial role of HDL by attenuating the build-up of oxidized lipids in LDL.
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Autoxidation of lipids and antioxidation by alpha-tocopherol and ubiquinol in homogeneous solution and in aqueous dispersions of lipids: unrecognized consequences of lipid particle size as exemplified by oxidation of human low density lipoprotein
TL;DR: The conclusions imply that the search for better antiatherosclerotic drugs might profitably focus on antioxidants capable of exporting radicals from LDL particles or otherwise increasing the traffic of radicals between particles.